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丝素蛋白-g-PNIPAM 通过酪氨酸-NIPAM 桥接的接枝与交联。

Grafting versus Crosslinking of Silk Fibroin-g-PNIPAM via Tyrosine-NIPAM Bridges.

机构信息

Advanced Polymer Materials Group, Department of Bioresources and Polymer Science, Politehnica University of Bucharest, 011061 Bucharest, Romania.

Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, 011061 Bucharest, Romania.

出版信息

Molecules. 2019 Nov 13;24(22):4096. doi: 10.3390/molecules24224096.

DOI:10.3390/molecules24224096
PMID:31766195
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6891396/
Abstract

This paper reports the synthesis and complex characterization of novel polymeric networks based on the crosslinking of silk fibroin via poly(-isopropylacrylamide) bridges generated by an ammonium cerium nitrate redox system. The research study gives an understanding of the polymerization mechanism in terms of the generation of radical sites, radical growth and termination reaction, as well as the involvement of modifications on silk fibroin structure and properties. The physico-chemical characterization was carried out by FTIR-ATR, X-ray photoelectron spectroscopy and RAMAN spectroscopy with unravelling the chemical modification. The structural characterization and spatial arrangement by secondary structure were carried out by X-ray diffraction and circular dichroism. The thermal behavior and thermal stability were evaluated by differential scanning calorimetry and thermogravimetric analysis. The novel complex polymer network is intended to be used in the field of smart drug delivery systems.

摘要

本文报道了通过硝酸铈铵氧化还原体系生成的聚（异丙基丙烯酰胺）桥交联丝素纤维，合成新型聚合网络的方法及复杂特性。该研究从自由基生成、自由基生长和终止反应以及丝素纤维结构和性能的修饰等方面，深入了解了聚合机理。通过傅里叶变换衰减全反射红外光谱、X 射线光电子能谱和拉曼光谱对物理化学特性进行了表征，揭示了化学修饰。通过 X 射线衍射和圆二色性对结构特性和二级结构的空间排列进行了研究。通过差示扫描量热法和热重分析评估了热行为和热稳定性。新型复合聚合物网络拟用于智能药物输送系统领域。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f036/6891396/0fbe56ac1beb/molecules-24-04096-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f036/6891396/2e4b3eed1cd2/molecules-24-04096-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f036/6891396/ced1b19a72b7/molecules-24-04096-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f036/6891396/f3984215b50f/molecules-24-04096-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f036/6891396/135c053c90a0/molecules-24-04096-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f036/6891396/874ebfc2232c/molecules-24-04096-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f036/6891396/51314be1deb3/molecules-24-04096-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f036/6891396/298e7117fed9/molecules-24-04096-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f036/6891396/7ddde18ee3e2/molecules-24-04096-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f036/6891396/7eadb8bd337a/molecules-24-04096-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f036/6891396/b4d9e8bcbdec/molecules-24-04096-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f036/6891396/241faf37ff4f/molecules-24-04096-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f036/6891396/0fbe56ac1beb/molecules-24-04096-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f036/6891396/2e4b3eed1cd2/molecules-24-04096-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f036/6891396/ced1b19a72b7/molecules-24-04096-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f036/6891396/f3984215b50f/molecules-24-04096-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f036/6891396/135c053c90a0/molecules-24-04096-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f036/6891396/874ebfc2232c/molecules-24-04096-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f036/6891396/51314be1deb3/molecules-24-04096-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f036/6891396/298e7117fed9/molecules-24-04096-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f036/6891396/7ddde18ee3e2/molecules-24-04096-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f036/6891396/7eadb8bd337a/molecules-24-04096-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f036/6891396/b4d9e8bcbdec/molecules-24-04096-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f036/6891396/241faf37ff4f/molecules-24-04096-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f036/6891396/0fbe56ac1beb/molecules-24-04096-g012.jpg

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本文引用的文献

[1]
Effect of Temperature Changes on Serum Protein Adsorption on Thermoresponsive Cell-Culture Surfaces Monitored by A Quartz Crystal Microbalance with Dissipation.

Int J Mol Sci. 2018-5-18

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Acta Biomater. 2017-11-1

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Molecules. 2017-8-18

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Int J Biol Macromol. 2011-11-28

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