用于生物传感的有机电化学晶体管阵列的制造。
Fabrication of organic electrochemical transistor arrays for biosensing.
作者信息
Zhang Meng, Lin Peng, Yang Mo, Yan Feng
机构信息
Department of Applied Physics and Materials Research Centre, The Hong Kong Polytechnic University, Hong Kong, China.
出版信息
Biochim Biophys Acta. 2013 Sep;1830(9):4402-6. doi: 10.1016/j.bbagen.2012.08.029. Epub 2012 Sep 7.
BACKGROUND
Organic electrochemical transistors (OECT) have been used as various types of biosensors with very high sensitivity. The OECTs show advantages of easy fabrication, low operational voltage, excellent flexibility and biocompatibility.
METHODS
OECT arrays based on poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) were fabricated in poly(ethylene glycol) (PEG) microwells by physical delamination.
RESULTS
The OECTs show fast response time, stable channel current and excellent transistor characteristics. The PEG microwells can be used to trap cells on top of the OECTs, which will be important for the application of the OECT arrays as cell-based biosensors.
GENERAL SIGNIFICANCE
This technique provides a feasible way for high-throughput cell analysis based on transistor arrays. This article is part of a Special Issue entitled Organic Bioelectronics-Novel Applications in Biomedicine.
背景
有机电化学晶体管（OECT）已被用作具有极高灵敏度的各类生物传感器。OECT具有易于制造、工作电压低、出色的柔韧性和生物相容性等优点。
方法
基于聚（3,4-乙撑二氧噻吩）：聚（苯乙烯磺酸盐）（PEDOT:PSS）的OECT阵列通过物理分层法在聚乙二醇（PEG）微孔中制备。
结果
这些OECT显示出快速的响应时间、稳定的沟道电流和出色的晶体管特性。PEG微孔可用于在OECT顶部捕获细胞，这对于将OECT阵列用作基于细胞的生物传感器的应用至关重要。
普遍意义
该技术为基于晶体管阵列的高通量细胞分析提供了一种可行的方法。本文是名为“有机生物电子学——在生物医学中的新应用”的特刊的一部分。
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