多胺与细胞3',5'-环磷酸腺苷

Polyamines and cellular adenosine 3' :5'-cyclic monophosphate.

作者信息

Clô C, Caldarera C M, Tantini B, Benalal D, Bachrach U

出版信息

Biochem J. 1979 Sep 15;182(3):641-9. doi: 10.1042/bj1820641a.

DOI:10.1042/bj1820641a

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1161396/

Abstract

The effect of polyamines on the cellular concentrations of cyclic AMP was studied. It was shown that 1 microM-spermine caused a decrease in cyclic AMP in chick-embryo heart cells, chick-embryo fibroblasts, neuroblastoma, glioma and neuroblastoma-glioma hybrid cells, grown in culture. A similar decrease was observed when polyamines were added to cells in the presence of a phosphodiesterase inhibitor or after stimulating the cells with various hormones. Noradrenaline was used in cultures of heart cells, prostaglandin E1 and adenosine for neuroblastoma and neuroblastoma-glioma hybrids, whereas isoproterenol was used for the stimulation of glioma cells. Polyamines at higher concentrations were either without effect or caused a slight increase in cyclic AMP. Spermidine (10 microM) also caused a decrease in cellular cyclic AMP, as did 0.1 microM-putrescine. It is suggested that the effect of polyamines on cellular cyclic AMP may be explained by the effect of these polycations on the activity of cellular phosphodiesterase.

摘要

研究了多胺对细胞内环磷酸腺苷（cAMP）浓度的影响。结果表明，在培养的鸡胚心脏细胞、鸡胚成纤维细胞、神经母细胞瘤、胶质瘤以及神经母细胞瘤 - 胶质瘤杂交细胞中，1微摩尔精胺会导致cAMP减少。当在磷酸二酯酶抑制剂存在的情况下向细胞中添加多胺，或用各种激素刺激细胞后，也观察到了类似的减少。在心脏细胞培养中使用去甲肾上腺素，在神经母细胞瘤和神经母细胞瘤 - 胶质瘤杂交细胞培养中使用前列腺素E1和腺苷，而在胶质瘤细胞刺激中使用异丙肾上腺素。较高浓度的多胺要么没有效果，要么会导致cAMP略有增加。亚精胺（10微摩尔）也会导致细胞内cAMP减少，0.1微摩尔腐胺也有同样的效果。有人提出，多胺对细胞内cAMP的影响可能是由这些多阳离子对细胞磷酸二酯酶活性的影响来解释的。

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本文引用的文献

1

Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。

J Biol Chem. 1951 Nov;193(1):265-75.

2

SPERMINE AND SPERMIDINE IN BLOOD CELLS, AND A POSSIBLE OCCURRENCE OF SPERMINE IN CELL NUCLEUS.血细胞中的精胺和亚精胺，以及精胺在细胞核中可能的存在情况。

Arch Biochem Biophys. 1965 May;110:368-72. doi: 10.1016/0003-9861(65)90136-0.

3

Regulation of spontaneous activity and growth of embryonic chick heart cells in tissue culture.组织培养中鸡胚心脏细胞自发活动和生长的调节

Dev Biol. 1967 Sep;16(3):216-49. doi: 10.1016/0012-1606(67)90025-5.

4

Putrescine and related amines as growth factors for a mammalian cell line.腐胺及相关胺类作为一种哺乳动物细胞系的生长因子。

Biochem Biophys Res Commun. 1964;14:34-8. doi: 10.1016/0006-291x(63)90206-7.

5

The dynamics of synthesis and degradation of polyamines in normal and regenerating rat liver and brain.正常和再生大鼠肝脏及大脑中多胺合成与降解的动力学

J Biol Chem. 1970 Dec 25;245(24):6732-8.

6

Regulation of amino acid decarboxylation.氨基酸脱羧作用的调节

Annu Rev Biochem. 1974;43(0):303-25. doi: 10.1146/annurev.bi.43.070174.001511.

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Effect of cyclic nucleotides on the induction of ornithine decarboxylase in BHK cells by serum and insulin.环核苷酸对血清和胰岛素诱导BHK细胞中鸟氨酸脱羧酶的影响。

Cell. 1974 Aug;2(4):229-33. doi: 10.1016/0092-8674(74)90015-4.

8

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