两种培养的成纤维细胞类型中，血清及环磷酸腺苷依赖性鸟氨酸脱羧酶活性调节的细胞类型差异。
Cell-type differences in the serum and cyclic AMP-dependent regulation of ornithine decarboxylase activity in two cultured fibroblast types.
作者信息
Boucek R J, Weiss J, Lembach K J
出版信息
Biochem J. 1982 Apr 15;204(1):357-60. doi: 10.1042/bj2040357.
Abstract
Serum re-feeding stimulated ornithine decarboxylase (ODC) activity 8 to 10-fold in FS fibroblasts and 5 to 8-fold in 3T3 fibroblasts. Addition of dibutyryl cyclic AMP or 3-isobutyl-1-methylxanthine at the time of serum re-feeding further stimulated ODC activity in 3T3 fibroblasts but inhibited the serum stimulation of ODC activity in FS fibroblasts. It is suggested that serum and cyclic AMP independently regulate ODC activity in cultured fibroblasts.
摘要
血清再喂养使FS成纤维细胞中的鸟氨酸脱羧酶（ODC）活性提高了8至10倍，使3T3成纤维细胞中的ODC活性提高了5至8倍。在血清再喂养时添加二丁酰环磷酸腺苷或3-异丁基-1-甲基黄嘌呤可进一步刺激3T3成纤维细胞中的ODC活性，但抑制FS成纤维细胞中血清对ODC活性的刺激。提示血清和环磷酸腺苷在培养的成纤维细胞中独立调节ODC活性。
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