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转化研究评估框架:以澳大利亚“健康起来”信息与指导服务(R)为例

Evaluation framework for translational research: case study of Australia's get healthy information and coaching service(R).

作者信息

O'Hara Blythe J, Bauman Adrian E, Eakin Elizabeth G, King Lesley, Haas Marion, Allman-Farinelli Margaret, Owen Neville, Cardona-Morell Magnolia, Farrell Louise, Milat Andrew J, Phongsavan Philayrath

机构信息

Prevention Research Collaboration, Sydney School of Public Health, University of Sydney, Sydney, New South Wales, Australia.

出版信息

Health Promot Pract. 2013 May;14(3):380-9. doi: 10.1177/1524839912456024. Epub 2012 Sep 14.

DOI:10.1177/1524839912456024
PMID:22982704
Abstract

The Get Healthy Information and Coaching Service® (GHS), a free government-funded telephone-delivered information and coaching service was launched in February 2009 by the Australian New South Wales state government. It represents the translation of research evidence applied in the real world (T4 or Phase 4 translation), aimed at addressing the modifiable risk factors associated with the overweight and obesity. In controlled settings, it has been established that telephone-based lifestyle counseling programs are efficacious in reducing anthropometric and behavioral risk factors. This article presents the GHS case study as a population-wide intervention and describes the quasi-experimental evaluation framework used to evaluate both the process (statewide implementation) and impact (effectiveness) of the GHS in a real-world environment. It details the data collection, measures, and statistical analysis required in assessing the process of implementation-reach and recruitment, marketing and promotion, service satisfaction, intervention fidelity, and GHS setting up and operations costs-and in assessing the impact of GHS-increasing physical activity, improving dietary practices, and reducing body weight and waist circumference. The comprehensive evaluation framework designed for the GHS provides a method for building effectiveness evidence of a rare translation of efficacy trial evidence into population-wide practice.

摘要

“健康信息与指导服务”(GHS)是一项由澳大利亚新南威尔士州政府于2009年2月推出的免费政府资助电话信息与指导服务。它代表了将研究证据应用于现实世界(转化医学4期或第4阶段转化),旨在解决与超重和肥胖相关的可改变风险因素。在可控环境中,已证实基于电话的生活方式咨询项目在降低人体测量和行为风险因素方面是有效的。本文将GHS案例研究作为一项全人群干预措施进行介绍,并描述了用于评估GHS在现实环境中的过程(全州范围实施)和影响(有效性)的准实验评估框架。它详细说明了在评估实施过程(覆盖范围和招募、营销与推广、服务满意度、干预保真度以及GHS的设立和运营成本)以及评估GHS的影响(增加身体活动、改善饮食习惯、减轻体重和腰围)时所需的数据收集、测量和统计分析。为GHS设计的综合评估框架提供了一种方法,用于构建将疗效试验证据罕见地转化为全人群实践有效性的证据。

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