Constantinovits M, Sipos F, Molnár B, Tulassay Zs, Műzes Gy
Faculty of Medicine, Semmelweis University, Budapest, Hungary.
Acta Physiol Hung. 2012 Sep;99(3):344-52. doi: 10.1556/APhysiol.99.2012.3.11.
Gut-associated lymphoid tissue (GALT) is supposed to play an integral role in the organization of colonic repair mechanisms. Majority of the GALT is composed of isolated and aggregated lymphoid follicles distributed throughout the intestines. These lymphoid follicles, including Peyer's patches of the small, and isolated lymphoid follicles (ILFs) of both the small and large intestines, are composed of a specialised follicle associated epithelium overlying a subepithelial dome containing numerous dendritic cells, macrophages, T and B cells. Within inflammatory conditions the number, the diameter and the density of ILFs are increasing. Follicles are involved not just in immune surveillance, but their presence is also indispensable for normal colonic mucosal regeneration. Regarding mucosal repair the relation of ILFs to bone marrow derived stem cells, follicular dendritic cells, subepithelial myofibroblasts and crypt formations, and the putative organizer role of ILFs have not been clarified yet.
肠道相关淋巴组织（GALT）被认为在结肠修复机制的组织中起着不可或缺的作用。大多数GALT由分布在整个肠道的孤立和聚集的淋巴滤泡组成。这些淋巴滤泡，包括小肠的派尔集合淋巴结以及小肠和大肠的孤立淋巴滤泡（ILF），由覆盖在含有大量树突状细胞、巨噬细胞、T细胞和B细胞的上皮下圆顶上方的特殊滤泡相关上皮组成。在炎症状态下，ILF的数量、直径和密度会增加。滤泡不仅参与免疫监视，而且它们的存在对于正常结肠黏膜再生也是不可或缺的。关于黏膜修复，ILF与骨髓来源的干细胞、滤泡树突状细胞、上皮下肌成纤维细胞和隐窝形成之间的关系以及ILF假定的组织者作用尚未阐明。
