World J Gastroenterol. 2011 Apr 7;17(13):1666-73. doi: 10.3748/wjg.v17.i13.1666.
Gut-associated lymphoid tissue is supposed to play a central role in both the organization of colonic repair mechanisms and colorectal carcinogenesis. In inflammatory conditions, the number, diameter and density of isolated lymphoid follicles (ILFs) increases. They are not only involved in immune surveillance, but their presence is also indispensable in normal mucosal regeneration of the colon. In carcinogenesis, ILFs may play a dual role. On the one hand they may support tumor growth and the metastatic process by vascular endothelial growth factor receptor signaling and producing a specific cytokine and cellular milieu, but on the other hand their presence is sometimes associated with a better prognosis. The relation of ILFs to bone marrow derived stem cells, follicular dendritic cells, subepithelial myofibroblasts or crypt formation, which are all involved in mucosal repair and carcinogenesis, has not been directly studied. Data about the putative organizer role of ILFs is scattered in scientific literature.
肠相关淋巴组织在结肠修复机制的组织和结直肠癌发生中都起着核心作用。在炎症状态下，孤立淋巴滤泡（ILF）的数量、直径和密度增加。它们不仅参与免疫监视，而且在结肠正常黏膜再生中也是必不可少的。在癌变过程中，ILF 可能发挥双重作用。一方面，它们可以通过血管内皮生长因子受体信号传导和产生特定的细胞因子和细胞微环境来支持肿瘤生长和转移过程，但另一方面，它们的存在有时与更好的预后相关。ILF 与骨髓来源的干细胞、滤泡树突状细胞、黏膜下肌纤维母细胞或隐窝形成的关系，这些都涉及黏膜修复和癌变，尚未直接研究。关于 ILF 潜在组织者作用的数据散见于科学文献中。
