Ansamitocin P-3, a maytansinoid, from Claopodium crispifolium and Anomodon attenuatus or associated actinomycetes. - Suppr | 超能文献

Ansamitocin P-3, a maytansinoid, from Claopodium crispifolium and Anomodon attenuatus or associated actinomycetes.

作者信息

Suwanborirux K, Chang C J, Spjut R W, Cassady J M

机构信息

Department of Medicinal Chemistry, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, Indiana 47907.

出版信息

Experientia. 1990 Jan 15;46(1):117-20. doi: 10.1007/BF01955435.

DOI:10.1007/BF01955435

Abstract

Guided by cytotoxicity, ansamitocin P-3, a maytansinoid, was isolated in very low yield from two members of the moss family Thuidiaceae, Claopodium crispifolium (Hook.) Ren. & Card. and Anomodon attenuatus (Hedw.) Hueb. Ansamitocin P-3 showed potent cytotoxicity against the human solid tumor cell lines A-549, HT-29. A possible basis for the occurrence of this compound in mosses is discussed.

摘要

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本文引用的文献

1

Antitumor principles in mosses: the first isolation and identification of maytansinoids, including a novel 15-methoxyansamitocin P-3.

J Nat Prod. 1988 Sep-Oct;51(5):845-50. doi: 10.1021/np50059a005.