Elsharif Mohamed E, Malik Elfatih M, Imam Mohamed E, Omran Mustafa O, Elsharif Elham G
Department of Nephrology, Gezira Hospital for Renal Diseases, Khartoum, Sudan.
Saudi J Kidney Dis Transpl. 2012 Sep;23(5):1099-103. doi: 10.4103/1319-2442.100970.
Malaria is endemic all over Sudan. The population are at risk of malaria infection to variable degrees. Kidney-transplanted patients on maintenance immunosuppressive therapy are known to be prone to infection, but there is not enough data in the medical literature as to whether they are more susceptible to malaria infection in endemic areas. This study was conducted in the Gezira Hospital for Renal Diseases and Surgery to assess the effect of maintenance immunosuppressive therapy in renal transplantation on malaria incidence. A total of 110 individuals were enrolled: 55 were renal-transplanted patients with end-stage renal disease who received kidney transplantation at least one year earlier and were on maintenance immunosuppressive medications. The other 55 individuals were the compatible healthy group. Thorough follow-up was exercised for both groups for one year (January-December 2009). Following the World Health Organization criteria for malaria diagnosis, a total of 51 malarial attacks were reported in both the groups, 25 in the transplanted group and 26 in the controls. The incidence difference between both groups was statistically insignificant [0.76 (± 1.170) and 1.09 (± 1.917) P = 0.282 among transplanted group and control group, respectively]. Providing routine malaria prophylaxis is not required for renal transplant recipients on maintenance immunosuppressive.
疟疾在苏丹全国流行。民众都不同程度地面临疟疾感染风险。已知接受维持性免疫抑制治疗的肾移植患者容易感染，但医学文献中没有足够数据表明他们在疟疾流行地区是否更容易感染疟疾。本研究在杰济拉肾病与外科医院开展，以评估肾移植维持性免疫抑制治疗对疟疾发病率的影响。共纳入110人：55名是患有终末期肾病的肾移植患者，他们至少在一年前接受了肾移植且正在接受维持性免疫抑制药物治疗。另外55人是匹配的健康组。对两组进行了为期一年（2009年1月至12月）的全面随访。按照世界卫生组织疟疾诊断标准，两组共报告了51次疟疾发作，移植组25次，对照组26次。两组之间的发病率差异无统计学意义[移植组和对照组分别为0.76（±1.170）和1.09（±1.917），P = 0.282]。接受维持性免疫抑制治疗的肾移植受者无需进行常规疟疾预防。
