Department of Dermatology, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan.
Acta Derm Venereol. 2013 May;93(3):314-8. doi: 10.2340/00015555-1454.
Herpes zoster occurs with increased frequency in patients with systemic lupus erythematosus (SLE). The aim of this study was to identify and evaluate clinical and laboratory risk factors associated with development of herpes zoster in patients with SLE. A retrospective case-control study was performed in a population of patients with SLE. Patients were identified as cases if their first episode of herpes zoster occurred after diagnosis of SLE. Patients with SLE who never developed herpes zoster were enrolled as controls. Medical charts and laboratory data for both cases and control patients were comprehensively reviewed. A total of 65 cases and 105 controls were included. Risk factors associated with the development of herpes zoster in patients with SLE were found to be lymphopaenia, anti-Ro antibodies, anti-RNP antibodies, neuropsychiatric manifestations, renal involvement and cyclophosphamide use. Therefore, the presence of certain disease manifestations in patients with SLE represents risk factors for the development of herpes zoster.
带状疱疹在系统性红斑狼疮（SLE）患者中的发生频率增加。本研究旨在确定并评估与 SLE 患者带状疱疹发展相关的临床和实验室危险因素。在 SLE 患者人群中进行了回顾性病例对照研究。如果患者的带状疱疹首发于 SLE 诊断后，则将其确定为病例。将从未发生过带状疱疹的 SLE 患者作为对照纳入。全面回顾了病例和对照患者的病历和实验室数据。共纳入 65 例病例和 105 例对照。发现与 SLE 患者带状疱疹发展相关的危险因素是淋巴细胞减少、抗 Ro 抗体、抗 RNP 抗体、神经精神表现、肾脏受累和环磷酰胺使用。因此，SLE 患者存在某些疾病表现代表带状疱疹发展的危险因素。
