区域和立体选择性钯催化降冰片烯衍生物与分子氧的环丙烷化反应，其中分子氧是唯一的氧化剂。
A regio- and diastereoselective palladium-catalyzed cyclopropanation of norbornene derivatives with molecular oxygen as the sole oxidant.
机构信息
School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, China.
出版信息
Chem Commun (Camb). 2012 Oct 25;48(83):10340-2. doi: 10.1039/c2cc35124b.
PMID:22983140
Abstract
A mild and efficient Pd-catalyzed cyclopropanation of norbornene derivatives with tertiary propargylic alcohols using molecular oxygen as the sole oxidant is described. This process allows quick and atom-economical assembly of various 1,2,3-trisubstituted cyclopropanes bearing α,β-unsaturated ketone moieties in high yields as a single regio- and diastereoisomer.
摘要
本文描述了一种温和高效的钯催化的降冰片烯衍生物与叔炔丙醇的环丙烷化反应，该反应以分子氧为唯一氧化剂。该过程可以快速、原子经济性地构建各种 1,2,3-三取代的环丙烷，这些环丙烷具有α,β-不饱和酮部分，产率高，且为单一区域和非对映异构体。
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