通过 Pd 催化吲哚-甲酰胺与炔烃的直接脱氢环化（DDA）反应，以空气为氧化剂合成β-和γ-咔啉酮。
Synthesis of beta- and gamma-carbolinones via Pd-catalyzed direct dehydrogenative annulation (DDA) of indole-carboxamides with alkynes using air as the oxidant.
机构信息
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Road 38, Beijing 100083, China.
出版信息
Org Lett. 2010 Jul 2;12(13):2908-11. doi: 10.1021/ol1007839.
PMID:20515016
Abstract
A palladium-catalyzed direct dehydrogenative annulation (DDA) of indolecarboxamides with internal alkynes via C-H and N-H bond cleavage using air as the oxidant was developed. With this method, both beta- and gamma-carbolinones can be easily prepared under the mild conditions.
摘要
钯催化吲哚甲酰胺与内部炔烃通过 C-H 和 N-H 键断裂的直接脱氢环化（DDA）反应，以空气作为氧化剂被开发出来。使用这种方法，在温和的条件下可以很容易地制备β-和γ-咔啉酮。
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