Kotov A S
Zh Nevrol Psikhiatr Im S S Korsakova. 2012;112(6 Pt 2):45-8.
We studied 279 women, aged 18-40 years old, with epilepsy. The study included the evaluation of anamnesis, clinical and neurological examination, routine EEG and/or video-EEG-monitoring, MRI of the brain. The period of observation was 6 months - 8 years. Idiopathic generalized epilepsy (IGE) was diagnosed in 85 cases, cryptogenic focal epilepsy in 107 cases, symptomatic focal epilepsy in 51 cases, unclassified epilepsy in 32 cases. In the end of study, remission was achieved in 70.8% of patients of the IGE group, the substantial reduction in the number of seizures was identified in 13.8%, no effect was seen in 15.4%. Adverse events were found in 22 of 63 (34.9%) patients treated with valproates, 9 of 25 (36%) patients treated with topiramate, 5 of 39 (1.8%) patients treated with carbamazepine, 3 of 7 (42.9%) patients treated with levetiracetam and in 2 of 5 (40%) patients treated with lamotrigine. The aggravation of absences with carbamazepine was diagnosed in 2 cases, myoclonic seizures - in 2 cases. Therapeutic strategies of young women with juvenile forms of IGE were described and analyzed.
我们研究了279名年龄在18至40岁之间的癫痫女性患者。该研究包括对既往史、临床和神经学检查、常规脑电图和/或视频脑电图监测、脑部磁共振成像的评估。观察期为6个月至8年。85例诊断为特发性全身性癫痫（IGE），107例为隐源性局灶性癫痫，51例为症状性局灶性癫痫，32例为未分类癫痫。研究结束时，IGE组70.8%的患者实现缓解，13.8%的患者癫痫发作次数大幅减少，15.4%的患者未见效果。在接受丙戊酸盐治疗的63例患者中有22例（34.9%）出现不良事件，接受托吡酯治疗的25例患者中有9例（36%），接受卡马西平治疗的39例患者中有5例（1.8%），接受左乙拉西坦治疗的7例患者中有3例（42.9%），接受拉莫三嗪治疗的5例患者中有2例（40%）。卡马西平导致失神发作加重2例，肌阵挛发作2例。描述并分析了患有青少年型IGE的年轻女性的治疗策略。
