RNA2DMap：一种RNA高阶结构信息的可视化探索工具。
RNA2DMap: A Visual Exploration Tool of the Information in RNA's Higher-Order Structure.
作者信息
Xu Weijia, Wongsa Ame, Lee Jung, Shang Lei, Cannone Jamie J, Gutell Robin R
机构信息
Texas Advanced Computing Center The University of Texas at Austin Austin, Texas, USA.
出版信息
Proceedings (IEEE Int Conf Bioinformatics Biomed). 2011:613-617. doi: 10.1109/BIBM.2011.60.
A new and emerging paradigm in molecular biology is revealing that RNA is implicated in nearly every aspect of the metabolism in the cell. To enhance our understanding of the function of these RNA molecules in the cell, it is essential that we have a complete understanding of their higher-order structures. While many computational tools have been developed to predict and analyse these higher-order RNA structures, few are able to visualize them for analytical purposes. In this paper, we present an interactive visualization tool of the secondary structure of RNA, named RNA2DMap. This program enables multiple-dimensions of information about RNA structure to be selected, customized and displayed to visually identify patterns and relationships. RNA2DMap facilitates the comparative analysis and understanding of RNAs that cannot be readily obtained with other graphical or text output from computer programs. Three use cases are presented to illustrate how RNA2DMap aids structural analysis.
分子生物学中一个新兴的范式表明，RNA几乎涉及细胞代谢的方方面面。为了加深我们对这些RNA分子在细胞中功能的理解，全面了解它们的高级结构至关重要。虽然已经开发了许多计算工具来预测和分析这些高级RNA结构，但能够将其可视化以供分析的工具却很少。在本文中，我们展示了一种名为RNA2DMap的RNA二级结构交互式可视化工具。该程序能够选择、定制并显示关于RNA结构的多维度信息，以便直观地识别模式和关系。RNA2DMap有助于对RNA进行比较分析和理解，而这是通过计算机程序的其他图形或文本输出无法轻易实现的。本文给出了三个用例来说明RNA2DMap如何辅助结构分析。
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