Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, 91054 Erlangen, Germany.
J Mol Med (Berl). 2012 Nov;90(11):1247-56. doi: 10.1007/s00109-012-0954-4. Epub 2012 Sep 15.
12/15-Lipoxygenase (12/15-LO) catalyzes the oxidation of free and esterified fatty acids thereby generating a whole spectrum of bioactive lipid mediators. This enzyme is involved in the regulation of various homeostatic processes as well as in the pathogenesis of multiple diseases. During the innate and adaptive immune response, 12/15-LO and its products exert both pro- and anti-inflammatory effects. Likewise, this enzyme has been implicated in the pathogenesis of autoimmune disease as well as in the maintenance of self-tolerance. This review will summarize our current knowledge about the role of 12/15-LO and will try to examine the two faces of this enzyme within the context of inflammation and immunity.
12/15-脂氧合酶（12/15-LO）催化游离脂肪酸和酯化脂肪酸的氧化，从而产生全谱生物活性脂质介质。这种酶参与各种体内平衡过程的调节以及多种疾病的发病机制。在先天和适应性免疫反应中，12/15-LO 及其产物发挥促炎和抗炎作用。同样，这种酶也与自身免疫性疾病的发病机制以及自身耐受的维持有关。这篇综述将总结我们目前对 12/15-LO 作用的认识，并试图在炎症和免疫的背景下探讨该酶的两面性。
