He Juan, Xu Guili
Department of Pharmacy, Kunming General Hospital of Chengdu Military Command, Kunming, 650032, China.
Tumour Biol. 2013 Oct;34(5):3131-6. doi: 10.1007/s13277-013-0881-1. Epub 2013 Jun 11.
The leptin (LEP) gene has been considered to be implicated in the development of cancer. However, the results have been inconsistent. In this study, we performed a meta-analysis to clarify the association of LEP rs7799039 variant with colorectal and prostate cancer risk. Published literatures from PubMed and Embase were retrieved. Pooled odds ratio (OR) with 95 % confidence interval (CI) was calculated using fixed or random effects model. A total of five studies (2,596 colorectal cancer cases and 3,240 controls) for association of LEP rs7799039 variant with colorectal cancer, and three studies (1,343 prostate cancer cases and 1,238 controls) for association with prostate cancer were included in the meta-analysis. For colorectal cancer, there was no significant association of LEP rs7799039 variant with this disease under homogeneous co-dominant model (OR = 0.88, 95 % CI = 0.75-1.02), heterogeneous co-dominant model (OR = 1.00, 95 % CI = 0.89-1.13) and dominant model (OR = 0.97, 95 % CI = 0.87-1.08); however, there was a marginal association under recessive model (OR = 0.87, 95 % CI = 0.76-0.99). For prostate cancer, there was significant association of LEP rs7799039 variant with this disease under homogeneous co-dominant model (OR = 1.33, 95 % CI = 1.06-1.67) and recessive model (OR = 1.26, 95 % CI = 1.05-1.51), but not under heterogeneous co-dominant model (OR = 1.24, 95 % CI = 0.87-1.77) and dominant model (OR = 1.30, 95 % CI = 1.84). The present meta-analysis demonstrated that the LEP rs7799039 variant was associated with prostate cancer, but not with colorectal cancer.
瘦素（LEP）基因被认为与癌症的发生有关。然而，研究结果并不一致。在本研究中，我们进行了一项荟萃分析，以阐明LEP rs7799039变异与结直肠癌和前列腺癌风险之间的关联。检索了来自PubMed和Embase的已发表文献。使用固定效应模型或随机效应模型计算合并比值比（OR）及其95%置信区间（CI）。共有五项研究（2596例结直肠癌病例和3240例对照）纳入了关于LEP rs7799039变异与结直肠癌关联的荟萃分析，三项研究（1343例前列腺癌病例和1238例对照）纳入了关于该变异与前列腺癌关联的荟萃分析。对于结直肠癌，在同质共显性模型（OR = 0.88，95%CI = 0.75 - 1.02）、异质共显性模型（OR = 1.00，95%CI = 0.89 - 1.13）和显性模型（OR = 0.97，95%CI = 0.87 - 1.08）下，LEP rs7799039变异与该疾病无显著关联；然而，在隐性模型下存在边缘关联（OR = 0.87，95%CI = 0.76 - 0.99）。对于前列腺癌，在同质共显性模型（OR = 1.33，95%CI = 1.06 - 1.67）和隐性模型（OR = 1.26，95%CI = 1.05 - 1.51）下，LEP rs7799039变异与该疾病有显著关联，但在异质共显性模型（OR = 1.24，95%CI = 0.87 - 1.77）和显性模型（OR = 1.30，95%CI = 1.84）下无显著关联。本荟萃分析表明，LEP rs7799039变异与前列腺癌有关，但与结直肠癌无关。
