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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Martin I, Colado I, del Val V, Alfaro M J

Department of Pharmacology, School of Medicine, Universidad Complutense, Madrid, Spain.

Gen Pharmacol. 1990;21(1):41-4. doi: 10.1016/0306-3623(90)90592-a.

The effects of three dihydropyridine derivates were studied and compared with those of nifedipine in guinea-pig ileum. 2. Nifedipine, nimodipine, nitrendipine (25-200 nM) and nisoldipine (10-80 nM) produced a dose-dependent inhibition of the contractile responses induced by single pulse stimulation, acetylcholine (1 microM) and high-K (50 mM). 3. From these experiments it is concluded that nimodipine and nitrendipine, like nifedipine, produced a similar and potent inhibitory effect of the contractile responses induced in the guinea-pig ileum. 4. Nisoldipine resulted to be the most active agent.

研究了三种二氢吡啶衍生物的作用，并与硝苯地平在豚鼠回肠中的作用进行了比较。2. 硝苯地平、尼莫地平、尼群地平（25 - 200 nM）和尼索地平（10 - 80 nM）对单脉冲刺激、乙酰胆碱（1 microM）和高钾（50 mM）诱导的收缩反应产生剂量依赖性抑制。3. 从这些实验得出结论，尼莫地平和尼群地平与硝苯地平一样，对豚鼠回肠诱导的收缩反应产生相似且有效的抑制作用。4. 尼索地平是最具活性的药物。

Martin I, Colado I, del Val V, Alfaro M J

Department of Pharmacology, School of Medicine, Universidad Complutense, Madrid, Spain.

Gen Pharmacol. 1990;21(1):41-4. doi: 10.1016/0306-3623(90)90592-a.

The effects of three dihydropyridine derivates were studied and compared with those of nifedipine in guinea-pig ileum. 2. Nifedipine, nimodipine, nitrendipine (25-200 nM) and nisoldipine (10-80 nM) produced a dose-dependent inhibition of the contractile responses induced by single pulse stimulation, acetylcholine (1 microM) and high-K (50 mM). 3. From these experiments it is concluded that nimodipine and nitrendipine, like nifedipine, produced a similar and potent inhibitory effect of the contractile responses induced in the guinea-pig ileum. 4. Nisoldipine resulted to be the most active agent.

研究了三种二氢吡啶衍生物的作用，并与硝苯地平在豚鼠回肠中的作用进行了比较。2. 硝苯地平、尼莫地平、尼群地平（25 - 200 nM）和尼索地平（10 - 80 nM）对单脉冲刺激、乙酰胆碱（1 microM）和高钾（50 mM）诱导的收缩反应产生剂量依赖性抑制。3. 从这些实验得出结论，尼莫地平和尼群地平与硝苯地平一样，对豚鼠回肠诱导的收缩反应产生相似且有效的抑制作用。4. 尼索地平是最具活性的药物。