Human Physiology Laboratory, Marywood University, Scranton, Pennsylvania, United States of America.
PLoS One. 2012;7(9):e44513. doi: 10.1371/journal.pone.0044513. Epub 2012 Sep 11.
(1) to examine the relation between pulmonary diffusing capacity and marathon finishing time, and (2), to evaluate the accuracy of pulmonary diffusing capacity for nitric oxide (DLNO) in predicting marathon finishing time relative to that of pulmonary diffusing capacity for carbon monoxide (DLCO).
28 runners [18 males, age = 37 (SD 9) years, body mass = 70 (13) kg, height = 173 (9) cm, percent body fat = 17 (7) %] completed a test battery consisting of measurement of DLNO and DLCO at rest, and a graded exercise test to determine running economy and aerobic capacity prior to the 2011 Steamtown Marathon (Scranton, PA). One to three weeks later, all runners completed the marathon (range: 2:22:38 to 4:48:55). Linear regressions determined the relation between finishing time and a variety of anthropometric characteristics, resting lung function variables, and exercise parameters.
In runners meeting Boston Marathon qualification standards, 74% of the variance in marathon finishing time was accounted for by differences in DLNO relative to body surface area (BSA) (SEE = 11.8 min, p<0.01); however, the relation between DLNO or DLCO to finishing time was non-significant in the non-qualifiers (p = 0.14 to 0.46). Whereas both DLCO and DLNO were predictive of finishing time for all finishers, DLNO showed a stronger relation (r(2) = 0.30, SEE = 33.4 min, p<0.01) compared to DLCO when considering BSA.
DLNO is a performance-limiting factor in only Boston qualifiers. This suggests that alveolar-capillary membrane conductance is a limitation to performance in faster marathoners. Additionally, DLNO/BSA predicts marathon finishing time and aerobic capacity more accurately than DLCO.
（1） 研究肺弥散量与马拉松完赛时间的关系，（2） 评估一氧化氮肺弥散量（DLNO）预测马拉松完赛时间的准确性相对于一氧化碳肺弥散量（DLCO）。
28 名跑步者[18 名男性，年龄=37（9）岁，体重=70（13）kg，身高=173（9）cm，体脂率=17（7）%]完成了一项测试，包括休息时测量 DLNO 和 DLCO，以及分级运动测试，以确定运动经济性和有氧能力，然后参加 2011 年斯克兰顿马拉松（宾夕法尼亚州斯克兰顿）。一到三周后，所有跑步者都完成了马拉松（时间范围：2:22:38 到 4:48:55）。线性回归确定了完赛时间与多种人体测量特征、静息肺功能变量和运动参数之间的关系。
在符合波士顿马拉松资格标准的跑步者中，马拉松完赛时间的 74%差异可以用 DLNO 与体表面积（BSA）的差异来解释（SEE=11.8 分钟，p<0.01）；然而，在不符合资格的人中，DLNO 或 DLCO 与完赛时间之间的关系不显著（p=0.14 到 0.46）。虽然 DLCO 和 DLNO 都可以预测所有完赛者的完赛时间，但当考虑 BSA 时，DLNO 与完赛时间的关系更强（r(2)=0.30，SEE=33.4 分钟，p<0.01）。
DLNO 是仅在波士顿资格赛者中限制表现的因素。这表明肺泡毛细血管膜通透性是更快马拉松运动员表现的限制因素。此外，DLNO/BSA 比 DLCO 更准确地预测马拉松完赛时间和有氧能力。
