在种族多样化、非工业化的环境中，父亲年龄与自闭症风险的关系：阿鲁巴岛。
Paternal age and risk of autism in an ethnically diverse, non-industrialized setting: Aruba.
机构信息
Child and Adolescent Psychiatry Clinic, Oranjestad, Aruba.
出版信息
PLoS One. 2012;7(9):e45090. doi: 10.1371/journal.pone.0045090. Epub 2012 Sep 11.
OBJECTIVE
The aim of this study was to examine paternal age in relation to risk of autism spectrum disorders (ASDs) in a setting other than the industrialized west.
DESIGN
A case-control study of Aruban-born children (1990-2003). Cases (N = 95) were identified at the Child and Adolescent Psychiatry Clinic, the only such clinic in Aruba; gender and age matched controls (N = 347) were gathered from public health records. Parental age was defined categorically (≤ 29, 30-39, 40-49, ≥ 50 y). The analysis was made, using conditional logistic regression.
RESULTS
Advanced paternal age was associated with increased risk of ASDs in offspring. In comparison to the youngest paternal age group (≤ 29 y), risk of autism increased 2.18 times for children born from fathers in their thirties, 2.71 times for fathers in their forties, and 3.22 thereafter.
CONCLUSION
This study, part of the first epidemiologic study of autism in the Caribbean, contributes additional evidence, from a distinctive sociocultural setting, of the risk of ASD associated with increased paternal age.
目的
本研究旨在非工业化西方环境中，检验父亲年龄与自闭症谱系障碍（ASD）风险之间的关系。
设计
阿鲁巴出生儿童（1990-2003 年）的病例对照研究。病例组（N=95）在阿鲁巴唯一的儿童和青少年精神病学诊所确定；按照性别和年龄匹配的对照组（N=347）来自公共卫生记录。父母年龄分为（≤29、30-39、40-49、≥50 岁）。使用条件逻辑回归进行分析。
结果
父亲年龄较大与后代 ASD 风险增加有关。与年龄最小的父亲年龄组（≤29 岁）相比，来自 30 多岁父亲的儿童患自闭症的风险增加了 2.18 倍，来自 40 多岁父亲的儿童增加了 2.71 倍，此后则增加了 3.22 倍。
结论
本研究是加勒比地区首例自闭症的流行病学研究之一，从独特的社会文化背景提供了更多证据，表明父亲年龄增加与 ASD 风险相关。
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