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足底糜烂性扁平苔藓:泼尼松的有效反应。

Erosive lichen planus of the soles: Effective response to prednisone.

机构信息

Dermatology Unit, Mongi Slim Hospital, Sidi Daoud, Tunis, 2046 Tunisia.

出版信息

Dermatol Ther (Heidelb). 2011 Sep;1(1):20-4. doi: 10.1007/s13555-011-0005-z. Epub 2011 Aug 22.

Abstract

BACKGROUND

Erosive lichen planus (LP) of the soles is a rare variant of LP, characterized by chronic, painful, and disabling plantar ulcerations. Herein, we report a case with complete healing following treatment with systemic steroids.

CASE REPORT

A 38-year-old woman was referred with painful and disabling erosive bilateral plantar LP, which she had experienced for 6 weeks. A 1 mg/kg/day, oral prednisone therapy led to rapid improvement and complete healing within 3 weeks, with a sustained result under a low dose maintenance therapy.

DISCUSSION

Ulcerative plantar LP is significantly known to be unresponsive to several topical and systemic therapies. Surgical excision and grafting is the treatment of choice. Systemic steroids are reported to have inefficient or partial results; both on cutaneous healing and on maintenance of the result. Our patient achieved complete cicatrisation with a sustained result of 3 months under a low dose of prednisone (5 mg/day).

摘要

背景

足底腐蚀性扁平苔藓(LP)是 LP 的一种罕见变异,其特征为慢性、疼痛和使人丧失能力的足底溃疡。在此,我们报告一例患者在接受全身类固醇治疗后完全愈合。

病例报告

一名 38 岁女性因双侧足底腐蚀性 LP 导致疼痛和丧失能力而被转介,她已经经历了 6 周。每日 1mg/kg 的口服泼尼松治疗导致在 3 周内迅速改善并完全愈合,在低剂量维持治疗下维持了持续的效果。

讨论

溃疡性足底 LP 明显对几种局部和全身治疗方法无反应。手术切除和植皮是首选治疗方法。据报道,全身类固醇的疗效不理想或部分有效;无论是在皮肤愈合方面,还是在维持治疗效果方面。我们的患者在接受低剂量泼尼松(5mg/天)治疗 3 个月后完全愈合,并取得了持续 3 个月的效果。

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