口服阿普司特治疗顽固性糜烂性口腔扁平苔藓和剥脱性龈炎
Treatment of recalcitrant erosive oral lichen planus and desquamative gingivitis with oral apremilast.
作者信息
AbuHilal Mohn'd, Walsh Scott, Shear Neil
机构信息
Division of Dermatology, Department of Medicine, Sunnybrook Health Sciences Center and University of Toronto, Toronto, Canada.
出版信息
J Dermatol Case Rep. 2016 Nov 30;10(3):56-57. doi: 10.3315/jdcr.2016.1232.
Abstract
BACKGROUND
Erosive oral lichen planus and desquamative gingivitis are uncommon but severe debilitating variants of oral lichen planus. Treatment of these presentations is difficult and challenging.
MAIN OBSERVATION
A 44-year-old woman was referred to the dermatology clinic with chronic painful lichen planus-related gingivitis and buccal erosions. She has failed multiple treatments including topical clobetasol and tacrolimus, intralesional corticosteroids and several systemic and immunosuppressive agents. Following completion of three months of treatment with oral apremilast at a dose of 30 mg twice daily, significant improvement was noted in her disease activity.
CONCLUSION
Oral apremilast may be a safe and effective treatment for erosive oral lichen planus.
摘要
背景
糜烂性口腔扁平苔藓和剥脱性龈炎是口腔扁平苔藓中罕见但严重的致残性变体。这些表现的治疗困难且具有挑战性。
主要观察结果
一名44岁女性因慢性疼痛性扁平苔藓相关牙龈炎和颊部糜烂被转诊至皮肤科诊所。她已经接受了多种治疗，包括外用氯倍他索和他克莫司、皮损内注射皮质类固醇以及几种全身性和免疫抑制剂，但均告失败。在每天两次口服30毫克阿普斯特治疗三个月后，其疾病活动度有显著改善。
结论
口服阿普斯特可能是治疗糜烂性口腔扁平苔藓的一种安全有效的方法。
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