Zigangirova N A, Nesterenko L N, Tiganova I G, Kost E A
Mol Gen Mikrobiol Virusol. 2012(3):3-13.
The role of the type-three secretion system of the gram-negative bacteria in regulation of chronic infections is discussed. Recent research showed that most of severe chronic somatic diseases are derived from chronic infection induced in the first place by infectious agents. The role of the T3SS of different species in transition from an acute infection to persistence is reviewed. Clinical and bacteriological research showed that microorganisms are persistent in the form resistant to antibiotics. That is why one of the promising targets for the development of antibacterial new-generation treatment is T3SS that conducts transport of bacteria pathogenicity factors into eukaryotic cell. The presence of this structure is necessary for the development of an acute infectious process and chronization of an infection is essential for its functioning.
讨论了革兰氏阴性菌的三型分泌系统在慢性感染调节中的作用。最近的研究表明，大多数严重的慢性躯体疾病最初源于感染因子引起的慢性感染。综述了不同物种的三型分泌系统在从急性感染转变为持续性感染过程中的作用。临床和细菌学研究表明，微生物以对抗生素耐药的形式持续存在。这就是为什么新一代抗菌治疗的一个有前景的靶点是将细菌致病因子转运到真核细胞中的三型分泌系统。这种结构的存在对于急性感染过程的发展是必要的，而感染的慢性化对其功能至关重要。
