Kuznetsova E M, Volokh O A, Shepelev I A, Nikiforov A K
Mol Gen Mikrobiol Virusol. 2012(3):22-5.
The structural characteristics of Francisella tularensis protective antigene complex (PAC) were discussed. PAC is the water-soluble antigene of outer membranes F. Tularensis with sophisticated chemical nature. The molecular weight of PAC is 280 kD. It was found that PAC is composed of some immunoreactivity protein subunits with molecular weight from 81 to 19 kD, and 14-17 kD lipoprotein subunit. The stress proteins-chaperones (GroES, GroEL), outer membrane proteins (FTL_0617, OmpH), receptor proteins (EF Tu, Rp1L), bacterial enzymes (KatG, GAPDH), and lipopolysaccharide were identified in the PAC structure. Their presence determines the PAC high immunobiological activity.
讨论了土拉弗朗西斯菌保护性抗原复合物（PAC）的结构特征。PAC是土拉弗朗西斯菌外膜的水溶性抗原，化学性质复杂。PAC的分子量为280kD。发现PAC由一些分子量为81至19kD的免疫反应性蛋白质亚基和14 - 17kD的脂蛋白亚基组成。在PAC结构中鉴定出应激蛋白 - 伴侣蛋白（GroES、GroEL）、外膜蛋白（FTL_0617、OmpH）、受体蛋白（EF Tu、Rp1L）、细菌酶（KatG、GAPDH）和脂多糖。它们的存在决定了PAC的高免疫生物学活性。
