Department of Pediatrics, Division of Neonatology, Faculty of Medicine, Erciyes University, Kayseri, 38039, Turkey.
Ital J Pediatr. 2012 Sep 17;38:44. doi: 10.1186/1824-7288-38-44.
We aimed to evaluate thyroid functions and volumes and detect abnormalities in 80 neonates with Down syndrome.
Data about free triiodothyronine, free thyroxine, thyroid stimulating hormone, thyroglobulin and urinary iodine levels, and ultrasonographic thyroid volume were collected.
Abnormal thyroid function tests were detected in 53.8% of the patients (n = 50) and these were hyperthyrotropinemia, hypothyroidism, iodine deficiency and iodine overload in 32, 2, 12 and 4 patients, respectively. Thyroid volumes were assessed in 36 patients and a total of 17 abnormalities were detected (7 hypoplasia, 3 agenesis and 7 goiter). In patients with hyperthyrotropinemia mean thyroid volume was significantly greater and mean TSH was significantly higher when compared to the patients without hyperthyrotropinemia.
Neonatal screening by thyroid function tests in Down syndrome should be performed to prevent further intellectual deterioration and improve overall development. In the neonatal period, the risk of hyperthyrotropinemia should be kept in mind.
我们旨在评估 80 例唐氏综合征新生儿的甲状腺功能和甲状腺体积，并检测异常情况。
收集游离三碘甲状腺原氨酸、游离甲状腺素、促甲状腺激素、甲状腺球蛋白和尿碘水平以及甲状腺超声体积的数据。
53.8%（n=50）的患者甲状腺功能检查异常，分别为 32 例高促甲状腺素血症、2 例甲状腺功能减退、12 例碘缺乏和 4 例碘过量。对 36 例患者进行了甲状腺体积评估，共发现 17 例异常（7 例发育不全、3 例发育不全和 7 例甲状腺肿）。与无高促甲状腺素血症的患者相比，高促甲状腺素血症患者的甲状腺体积明显增大，TSH 均值明显升高。
应通过甲状腺功能检查对唐氏综合征新生儿进行筛查，以预防进一步的智力恶化和改善整体发育。在新生儿期，应注意高促甲状腺素血症的风险。
