Corvò R, Merlano M, Looney W B, Benasso M, Bacigalupo A, Margarino G
Department of Radiotherapy, Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy.
Head Neck. 1990 Jan-Feb;12(1):60-5. doi: 10.1002/hed.2880120108.
From January 1987 to May 1988, 16 patients with advanced squamous cell carcinoma of the head and neck received combined treatment, based on an alternating schedule of chemotherapy and multiple fractions per day (MFD)-radiotherapy. The chemotherapy regimen consisted of cisplatin, 20 mg/m2, followed by 5-fluorouracil (5-FU), 200 mg/m2 i.v. push, from days 1 to 5 during weeks 1, 5, and 9. Radiotherapy was administered in two courses of 32 Gy each (total dose, 64 Gy) during weeks 2 and 3 and 6 and 7. Each course was given in two fractions per day, 5 days per week. The 16 patients were evaluated for toxicity and response. We observed 7 complete responders, 6 partial responders, and 3 nonresponders. The overall response rate was 81%. Toxicity was heavy: 44% of the patients developed grade III-IV mucositis. Our results suggest that cisplatin and 5-fluorouracil alternating with MFD-radiotherapy is effective; however, a new less toxic scheduling must be determined.
1987年1月至1988年5月，16例晚期头颈部鳞状细胞癌患者接受了联合治疗，治疗方案为化疗与每日多次分割放疗（MFD）交替进行。化疗方案为顺铂，20mg/m²，随后是5-氟尿嘧啶（5-FU），200mg/m²静脉推注，于第1、5、9周的第1至5天给药。放疗在第2和3周以及第6和7周分两个疗程进行，每个疗程32Gy（总剂量64Gy）。每个疗程每天分两次给药，每周5天。对这16例患者进行了毒性和疗效评估。我们观察到7例完全缓解者、6例部分缓解者和3例无反应者。总缓解率为81%。毒性反应严重：44%的患者出现III-IV级粘膜炎。我们的结果表明，顺铂和5-氟尿嘧啶与MFD放疗交替使用是有效的；然而，必须确定一种毒性较小的新方案。
