Chinese Acad Sci, Inst Subtrop Agr, Res Ctr Healthy Breeding Livestock & Poultry, Hunan Engn & Res Ctr Anim & Poultry Sci, Key Lab Agroecol Proc Subtrop Reg, Scientific Oberving and Experimetal Station of Animal Nutrition and Feed Science in South-Central, Ministry of Agriculture, Changsha, 410125 Hunan, China.
Mol Cell Endocrinol. 2013 Jan 5;365(1):44-51. doi: 10.1016/j.mce.2012.09.002. Epub 2012 Sep 8.
Although a growing body of evidence suggests that soy isoflavones help regulate lipid metabolism, the underlying mechanism has not yet been thoroughly clarified. The present study was undertaken to determine the effects of soy isoflavones on the expression of genes involved in lipid metabolism in different adipose tissue depots, skeletal muscle and liver of male Huanjiang mini-pigs, as well as the expression of adipokines and myokines. A total of 36 male Huanjiang mini-pigs were fed basal diet (control, Con), low-dose soy isoflavones (LSI) and high-dose soy isoflavones (HSI). The results showed that LSI and HSI regulated the expression of genes involved in the anabolism and catabolism of fatty acids in dorsal subcutaneous (DSA), abdominal subcutaneous (ASA) and perirenal (PRA) adipose tissue depots, as well as longissimus dorsi muscle (LDM) and liver. LSI and HSI also regulated the expression of adipokines in DSA, ASA and PRA, and the expression of myokines in LDM in male Huanjiang mini-pigs. In addition, soy isoflavones regulated plasma glucose, leptin and adiponectin contents after treatment for two months. Our results indicate that soy isoflavones, by regulating the expression of adipokines and myokines, may regulate the metabolism of lipids and could have potential therapeutic applications in lipid abnormalities.
尽管越来越多的证据表明大豆异黄酮有助于调节脂质代谢，但其中的机制尚未完全阐明。本研究旨在探讨大豆异黄酮对雄性环江小型猪不同脂肪组织（背侧皮下脂肪组织、腹侧皮下脂肪组织和肾周脂肪组织）、骨骼肌和肝脏中与脂质代谢相关基因的表达，以及对脂肪因子和肌因子表达的影响。将 36 头雄性环江小型猪分为对照组（Con）、低剂量大豆异黄酮组（LSI）和高剂量大豆异黄酮组（HSI），分别饲以基础日粮、低剂量大豆异黄酮日粮和高剂量大豆异黄酮日粮。结果表明，LSI 和 HSI 可调节背侧皮下脂肪组织（DSA）、腹侧皮下脂肪组织（ASA）和肾周脂肪组织（PRA）、背最长肌（LDM）和肝脏中脂肪酸合成与分解相关基因的表达。LSI 和 HSI 还可调节 DSA、ASA 和 PRA 中的脂肪因子以及 LDM 中的肌因子的表达。此外，大豆异黄酮可调节雄性环江小型猪血浆葡萄糖、瘦素和脂联素含量，且在治疗两个月后作用明显。本研究结果表明，大豆异黄酮通过调节脂肪因子和肌因子的表达，可能调节脂质代谢，在脂质异常的治疗中具有潜在的应用价值。
