环氧水解酶基因变异可改变汉族人群少弱精子症的发病风险。
Genetic variants in epoxide hydrolases modify the risk of oligozoospermia and asthenospermia in Han-Chinese population.
机构信息
State Key Laboratory of Reproductive Medicine, Institute of Toxicology, Nanjing Medical University, Nanjing 210029, China.
出版信息
Gene. 2012 Dec 1;510(2):171-4. doi: 10.1016/j.gene.2012.09.016. Epub 2012 Sep 14.
OBJECTIVES
Epoxide hydrolases are involved in detoxifying and excreting the environmental chemicals, which are associated with decreased semen quality and male infertility. We hypothesized that polymorphisms in epoxide hydrolases may be associated with risk of oligozoospermia and asthenospermia.
DESIGN AND METHODS
In this study, 468 fertile controls and 672 idiopathic male infertile patients were recruited. SNPstream and TaqMan assay were used to genotype four single nucleotide polymorphisms in EPHX1 and EPHX2. The semen analysis was performed by computer-assisted semen analysis system.
RESULTS
Our results demonstrated that rs1042064 of EPHX2 was significantly associated with decreased risk of oligozoospermia (OR=0.65, 95% CI: 0.44-0.98) and asthenospermia (OR=0.66, 95% CI: 0.46-0.94).
CONCLUSIONS
Our results provided evidence that genetic variants in epoxide hydrolases may modify the risk of oligozoospermia and asthenospermia in Han-Chinese population.
目的
环氧化物水解酶参与解毒和排泄环境化学物质，这些化学物质与精液质量下降和男性不育有关。我们假设环氧化物水解酶的多态性可能与少精子症和弱精子症的风险相关。
设计和方法
本研究招募了 468 名生育能力正常的对照组和 672 名特发性男性不育症患者。使用 SNPstream 和 TaqMan 检测方法对 EPHX1 和 EPHX2 中的四个单核苷酸多态性进行基因分型。通过计算机辅助精液分析系统进行精液分析。
结果
我们的结果表明，EPHX2 的 rs1042064 与少精子症（OR=0.65，95%CI：0.44-0.98）和弱精子症（OR=0.66，95%CI：0.46-0.94）的风险降低显著相关。
结论
我们的结果提供了证据，表明环氧化物水解酶的遗传变异可能改变汉族人群少精子症和弱精子症的风险。
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