The General Infirmary at Leeds, Great George Street, Leeds LS13EX, UK.
Br J Anaesth. 2013 Jan;110(1):74-80. doi: 10.1093/bja/aes320. Epub 2012 Sep 17.
There are few national figures on the incidence of failed tracheal intubation during general anaesthesia in obstetrics. Recent small studies have quoted a rate of one in 250 general anaesthetics (GAs). The aim of this UK national study was to estimate this rate and identify factors that may be predictors.
Using the UK Obstetric Surveillance System (UKOSS) of data collection, a survey was conducted between April 2008 and March 2010. Incidence and associated risk factors were recorded in consultant-led UK delivery suites. Units reported the details of any failed intubation (index case) and the two preceding GA cases (controls). Predictors were evaluated using multivariable logistic regression, significance P<0.05 (two-sided).
We received 57 completed reports (100% response). The incidence using a unit-based estimation approach was one in 224 (95% confidence interval 179-281). Univariate analyses showed the index cases to be significantly older, heavier, with higher BMI, with Mallampati score recorded and score >1. Multivariate analyses showed that age, BMI, and a recorded Mallampati score were significant independent predictors of failed tracheal intubation. The classical laryngeal mask airway was the most commonly used rescue airway (39/57 cases). There was one emergency surgical airway but no deaths or hypoxic brain injuries. Gastric aspiration occurred in four (8%) index cases. Index cases were more likely to have maternal morbidities (P=0.026) and many babies in both groups were admitted to the neonatal intensive care unit: 21 (37%) vs 29 (27%) (NS). Three babies died--all in the control group.
在全身麻醉期间行气管插管失败的发生率在产科领域鲜有全国性数据。最近的一些小型研究报告称,全身麻醉的发生率为每 250 例中有 1 例。本项英国全国性研究旨在评估这一发生率并确定可能的预测因素。
利用英国产科监测系统(UKOSS)的数据收集,于 2008 年 4 月至 2010 年 3 月间进行了一项调查。在由顾问领导的英国分娩室中记录了发生率和相关的危险因素。各单位报告了任何气管插管失败(索引病例)以及之前的 2 例全身麻醉病例(对照病例)的详细情况。使用多变量逻辑回归评估预测因子,双侧 P<0.05 有统计学意义。
我们收到了 57 份完成的报告(100%应答率)。采用基于单位的估计方法,发生率为每 224 例中有 1 例(95%置信区间 179-281)。单变量分析显示,索引病例明显更年长、更重、BMI 更高、Mallampati 评分记录且评分>1。多变量分析显示,年龄、BMI 和记录的 Mallampati 评分是气管插管失败的显著独立预测因素。经典的喉罩气道是最常用的抢救气道(39/57 例)。有 1 例紧急行外科气道,但无死亡或缺氧性脑损伤病例。4 例(8%)索引病例发生胃吸入。索引病例更可能出现母体合并症(P=0.026),两组中许多婴儿均入住新生儿重症监护病房:21 例(37%)vs 29 例(27%)(无统计学意义)。3 例婴儿死亡,均在对照组。