树突自回避：原钙黏蛋白提供保障。
Dendritic self-avoidance: protocadherins have it covered.
机构信息
Department of Neuroscience, Columbia University Medical Center, 630 W. 168th St. P&S 12-403, New York, NY 10032, USA.
出版信息
Cell Res. 2013 Mar;23(3):323-5. doi: 10.1038/cr.2012.137. Epub 2012 Sep 18.
Abstract
Dendrites exhibit self-avoidance, in which branches of the same neuron repel each other while overlapping with branches from neighboring neurons. A recent paper by Lefebvre and colleagues reveals that clustered protocadherins provide a basis for neuronal recognition during dendrite self-avoidance in vertebrates.
摘要
树突表现出自回避现象，即同一神经元的分支在与来自相邻神经元的分支重叠时相互排斥。Lefebvre 及其同事的一篇新论文揭示了聚类原钙黏蛋白为脊椎动物树突自回避过程中的神经元识别提供了基础。
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本文引用的文献
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Protocadherins mediate dendritic self-avoidance in the mammalian nervous system.原钙黏蛋白在哺乳动物神经系统中介导树突的自我回避。
Nature. 2012 Aug 23;488(7412):517-21. doi: 10.1038/nature11305.
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γ-protocadherins control cortical dendrite arborization by regulating the activity of a FAK/PKC/MARCKS signaling pathway.γ-原钙黏蛋白通过调节 FAK/PKC/MARCKS 信号通路的活性来控制皮质树突分支。
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gamma-Protocadherins regulate neuronal survival but are dispensable for circuit formation in retina.γ-原钙黏蛋白调节神经元存活，但对视网膜回路形成并非必需。
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Dendrite self-avoidance is controlled by Dscam.树突自我回避由唐氏综合征细胞粘附分子（Dscam）控制。
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