Departments of Neurobiology, Ophthalmology, and Cell Biology, Duke University School of Medicine, Durham, NC 27710, USA.
Departments of Neurobiology, Ophthalmology, and Cell Biology, Duke University School of Medicine, Durham, NC 27710, USA.
Curr Biol. 2024 Sep 23;34(18):R854-R856. doi: 10.1016/j.cub.2024.07.076.
Protocadherins are cell-surface proteins that endow developing neurons with the ability to distinguish self-contacts from non-self. This recognition is critical for dendrite patterning and neuronal function. New research demonstrates the cellular basis for dendrite self-avoidance following protocadherin-mediated self-recognition.
原钙黏蛋白是一种细胞表面蛋白,它使发育中的神经元具有区分自身接触与非自身接触的能力。这种识别对于树突模式形成和神经元功能至关重要。新的研究表明,原钙黏蛋白介导的自身识别后树突自我回避的细胞基础。