Vrijman Charlotte, Linthorst Homan May W, Limpens Jacqueline, van der Veen Wietze, Wolkerstorfer Albert, Terwee Caroline B, Spuls Phyllis I
Netherlands Institute for Pigment Disorders, Department of Dermatology, Academic Medical Center, University of Amsterdam, Meibergdreef 35, 1105 AZ Amsterdam, the Netherlands.
Arch Dermatol. 2012 Nov;148(11):1302-9. doi: 10.1001/archdermatol.2012.3065.
OBJECTIVE To summarize and critically appraise the evidence on the measurement properties of clinician-, patient-, and observer-reported outcomes, measuring any construct of interest in patients with all types of vitiligo. DATA SOURCES Electronic databases including PubMed (1948 to July 2011), OVID EMBASE (1980 to July 2011), and CINAHL (EBSCOhost) (1982 to July 2011) were searched. STUDY SELECTION Two authors independently screened all records for eligibility. For inclusion, the study population had to include patients with vitiligo, for which outcome measures were developed or evaluated on their measurement properties. The initial search retrieved 1249 records, of which 14 articles met the inclusion criteria. DATA EXTRACTION Characteristics of the included instruments, study population, and results of the measurement properties were extracted. The Consensus-Based Standards for the Selection of Health Status Measurement Instruments (COSMIN) 4-point checklist, combined with quality criteria for measurement properties, was used to calculate the overall level of evidence per measurement property of each instrument. Independent extraction and assessment was performed by 2 authors. DATA SYNTHESIS Eleven different measurement instruments were identified. Strong evidence was found for a positive internal consistency of the Dermatology Life Quality Index. For other instruments, the evidence of measurement properties was limited or unknown. CONCLUSIONS Recommendations on the use of specific outcome measures for vitiligo should be formulated with caution because current evidence is insufficient owing to a low number of studies with poor methodological quality and unclear clinical relevance. To recommend outcome measures for vitiligo, further research on measurement properties of clinical relevant outcome measures for vitiligo according to COSMIN quality criteria is needed.
总结并批判性评价关于临床医生报告、患者报告及观察者报告结局的测量属性的证据，测量所有类型白癜风患者的任何感兴趣的结构。数据来源：检索电子数据库，包括PubMed（1948年至2011年7月）、OVID EMBASE（1980年至2011年7月）和CINAHL（EBSCOhost）（1982年至2011年7月）。研究选择：两位作者独立筛选所有记录以确定其是否符合纳入标准。纳入标准为研究人群必须包括白癜风患者，且针对其测量属性制定或评估了结局指标。初步检索获得1249条记录，其中14篇文章符合纳入标准。数据提取：提取所纳入工具的特征、研究人群以及测量属性的结果。采用基于共识的健康状况测量工具选择标准（COSMIN）4分制清单，并结合测量属性的质量标准，计算每个工具各测量属性的总体证据水平。由两位作者进行独立提取和评估。数据综合：识别出11种不同的测量工具。发现皮肤病生活质量指数具有良好的内部一致性的有力证据。对于其他工具，测量属性的证据有限或未知。结论：由于研究数量少、方法学质量差且临床相关性不明确，当前证据不足，因此应谨慎制定关于白癜风特定结局指标使用的建议。为推荐白癜风的结局指标，需要根据COSMIN质量标准对白癜风临床相关结局指标的测量属性进行进一步研究。
