State Key Laboratory of Oncology in South China, Guangzhou, PR China.
Gynecol Obstet Invest. 2012;74(4):288-97. doi: 10.1159/000341706. Epub 2012 Sep 19.
We aimed to investigate the nature of endometrial stromal sarcoma (ESS) arising from endometriosis.
The clinical data of 5 patients with ESS arising from endometriosis were reviewed retrospectively. The expression of CD117, HER2/neu, EGFR, VEGF, and PDGFR was analyzed by immunohistochemical staining.
The median age of the 5 patients was 45 years. The primary tumor sites were the ovary in 2, the pelvis in 2, and the cervical canal in 1 patient. Three patients had disseminated disease at diagnosis. Four patients underwent complete tumor resection. All of the 5 cases received adjuvant chemotherapy and 2 received progesterone therapy, while none were treated with radiotherapy. No recurrence occurred in the 4 cases who had complete tumor resection, and the only patient who progressed was the patient in whom the tumor was unresectable. Tumor cells in all cases exhibited positive staining for PDGFR and were negative for CD117 and HER2/neu. The expression of EGFR and VEGF was observed in 2 and 4 cases, respectively.
ESS arising from endometriosis is rare. Complete tumor resection in ESS arising from endometriosis may reduce the recurrence rate.
我们旨在研究源于子宫内膜异位症的子宫内膜间质肉瘤（ESS）的性质。
回顾性分析 5 例源于子宫内膜异位症的 ESS 患者的临床资料。采用免疫组织化学染色法分析 CD117、HER2/neu、EGFR、VEGF 和 PDGFR 的表达。
5 例患者的中位年龄为 45 岁。原发肿瘤部位为卵巢 2 例，盆腔 2 例，宫颈 1 例。3 例患者在诊断时已发生播散性疾病。4 例患者接受了肿瘤完全切除术。所有 5 例患者均接受了辅助化疗，2 例接受了孕激素治疗，而无放疗。4 例完全切除肿瘤的患者均无复发，唯一进展的患者是肿瘤无法切除的患者。所有病例的肿瘤细胞均 PDGFR 阳性染色，而 CD117 和 HER2/neu 均为阴性。EGFR 和 VEGF 的表达分别在 2 例和 4 例中观察到。
源于子宫内膜异位症的 ESS 较为罕见。对源于子宫内膜异位症的 ESS 进行肿瘤完全切除可能会降低复发率。
