School of Computing and Mathematics, University of Ulster, Jordanstown, BT37 0QB, Northern Ireland, UK.
IEEE Trans Nanobioscience. 2012 Sep;11(3):244-50. doi: 10.1109/TNB.2012.2212720.
The idea of the existence of date and party hubs in protein-protein interaction networks has been debated since it was proposed in 2004. Based on the incorporation of the information extracted from known three-dimensional structures of protein interactions, we revisited the properties associated with date and party hubs previously identified. The correlation of genomic essentiality, gene coexpression, and functional semantic similarity with date and party hubs were examined. The number of interaction interfaces associated with each hub was taken into account. The results suggested that the identification of date and party hubs based on their network connectivity and expression profiles with interaction partners may be incomplete. The number of interaction interfaces could play an important role in examining functional and topological properties associated with each hub protein. The observation is robust to the choice of degree cutoffs for hubs. Furthermore, we found that while singlish-interface hubs seem to correspond mostly to date hub, it appears that there is no significant difference between the proportions of multi-interface proteins categorized as date and as party hubs.
自 2004 年提出以来，关于蛋白质-蛋白质相互作用网络中存在日期和聚会中心的观点一直存在争议。基于从已知蛋白质相互作用的三维结构中提取的信息，我们重新研究了与之前确定的日期和聚会中心相关的属性。检查了与日期和聚会中心相关的基因组必要性、基因共表达和功能语义相似性的相关性。考虑了与每个中心相关的相互作用界面的数量。结果表明，基于网络连接性和与相互作用伙伴的表达谱来识别日期和聚会中心可能不完整。相互作用界面的数量在检查与每个中心蛋白相关的功能和拓扑属性方面可能起着重要作用。这种观察结果对于中心的度截止值的选择是稳健的。此外，我们发现，虽然单界面中心似乎主要对应于日期中心，但分类为日期和聚会中心的多界面蛋白质的比例似乎没有显著差异。
