Rossmann Michael G
Department of Biological Sciences, Purdue University, West Lafayette, IN, USA.
Methods Mol Biol. 2013;932:1-4. doi: 10.1007/978-1-62703-065-6_1.
The history of the concept of protein folds is discussed, starting with the original concept of super-secondary structure. This has led to the recognition of a fairly small number of distinct folds defining individual domains within larger proteins. Each fold can usually be associated with a specific function. Thus the active site of an enzyme is likely to be at the boundary between domains, each contributing a simple function to a more complex process.
本文讨论了蛋白质折叠概念的历史，从超二级结构的原始概念开始。这导致人们认识到，在较大的蛋白质中，定义各个结构域的独特折叠数量相当少。每个折叠通常都可以与特定功能相关联。因此，酶的活性位点可能位于结构域之间的边界处，每个结构域为更复杂的过程贡献一个简单功能。
