Efimov Alexander V
Institute of Protein Research, Russian Academy of Sciences, Moscow Region, Russia.
Methods Mol Biol. 2013;932:177-89. doi: 10.1007/978-1-62703-065-6_11.
A characteristic feature of the polypeptide chain is its ability to form a restricted set of commonly occurring folding units composed of two or more elements of secondary structure that are adjacent along the chain. Some of these super-secondary structures exhibit a unique handedness and a unique overall fold irrespective of whether they occur in homologous or nonhomologous proteins. Such super-secondary structures are of particular value since they can be used as starting structures in protein modeling. The larger protein folds can be obtained by stepwise addition of other secondary structural elements to the starting structures taking into account a set of simple rules inferred from known principles of protein structure.
多肽链的一个特征是它能够形成一组有限的常见折叠单元，这些单元由沿着链相邻的两个或更多二级结构元件组成。其中一些超二级结构呈现出独特的手性和独特的整体折叠方式，无论它们出现在同源蛋白还是非同源蛋白中。这种超二级结构具有特殊价值，因为它们可以用作蛋白质建模的起始结构。考虑到从已知蛋白质结构原理推导出来的一组简单规则，通过向起始结构逐步添加其他二级结构元件，可以获得更大的蛋白质折叠结构。
