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Beyond supersecondary structure: the global properties of protein sequences.

作者信息

Rackovsky S

机构信息

Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York University, New York, NY, USA.

出版信息

Methods Mol Biol. 2013;932:107-14. doi: 10.1007/978-1-62703-065-6_7.

DOI:10.1007/978-1-62703-065-6_7
PMID:22987349
Abstract

Analysis of the global properties of protein sequences, rather than single-site or local properties, has been shown to lead to new understanding of folding and function. Here we describe the use of software which can describe sequences numerically in an orthonormal fashion, Fourier-analyze those sequences, and verify the statistical significance of the resulting Fourier coefficients. The resulting parameters can be used to study problems involving sequences from a unique perspective.

摘要

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