Department of Radiation Oncology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Head Neck. 2013 Oct;35(10):1507-14. doi: 10.1002/hed.23156. Epub 2012 Sep 18.
The correlation between vascular endothelial growth factor (VEGF) overexpression and the clinical outcome of head and neck cancer remains inconclusive. This meta-analysis aimed to evaluate the prognostic value of VEGF in patients with head and neck cancer.
We searched Ovid MEDLINE, EMBASE and 2 Chinese science databases in order to enroll all eligible articles. Forty-seven studies were included in this meta-analysis. All results were evaluated by the random-effects model.
VEGF overexpression is significantly associated with worse overall survival (OS; hazard ratio [HR], 1.89; 95% confidence interval [CI], 1.61-2.22) and progression-free survival (PFS; HR, 1.68; 95% CI, 1.33-2.12). Subgroup analysis reveals that VEGF overexpression is a significant poor predictor for nasopharyngeal cancer (HR, 1.66; 95% CI, 1.30-2.12) and salivary gland cancer (HR, 3.32; 95% CI, 1.61-6.84).
Our meta-analysis supports that VEGF overexpression is an available poor predictor for patients with head and neck cancer.
血管内皮生长因子（VEGF）过度表达与头颈部癌症的临床结果之间的相关性尚无定论。本荟萃分析旨在评估 VEGF 对头颈部癌症患者的预后价值。
我们在 Ovid MEDLINE、EMBASE 和 2 个中文科学数据库中进行检索，以纳入所有符合条件的文章。共有 47 项研究纳入本荟萃分析。所有结果均采用随机效应模型进行评估。
VEGF 过度表达与较差的总生存期（OS；风险比[HR]，1.89；95%置信区间[CI]，1.61-2.22）和无进展生存期（PFS；HR，1.68；95% CI，1.33-2.12）显著相关。亚组分析显示，VEGF 过度表达对头颈癌（HR，1.66；95% CI，1.30-2.12）和唾液腺癌（HR，3.32；95% CI，1.61-6.84）是一个显著的不良预测因素。
我们的荟萃分析支持 VEGF 过度表达是头颈部癌症患者的一个有价值的不良预测指标。
