Department of Otolaryngology, First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Head Neck. 2013 Oct;35(10):E304-7. doi: 10.1002/hed.23164. Epub 2012 Sep 18.
We report an extremely rare case of hypopharyngeal paraganglioma that was accompanied by a paraneoplastic neurologic syndrome (PNS).
The clinical, radiological, and histopathologic findings of the patient are presented.
A 49-year-old woman presented with a history of progressive asthenia of the lower extremities persisting for 2 months. She also experienced numbness and sensory disturbance of the left lower limbs, 2 epileptic seizures, and constipation during the period. Clinical and radiological evaluations suggested the diagnosis of encephalomyelitis in combination with a left hypopharyngeal mass lesion. The patient underwent surgical excision of the lesion, which subsequently resolved her symptoms. Postoperative pathology was consistent with a paraganglioma. There was no evidence of local recurrence or distant metastasis of the tumor on recent follow-up.
To the best of our knowledge, our patient represents the third reported case of hypopharyngeal paraganglioma, and the only one to have a paraneoplastic syndrome.
我们报告了一例极其罕见的咽旁副神经节瘤病例，该病例伴有副瘤性神经综合征（PNS）。
呈现了患者的临床、影像学和组织病理学发现。
一名 49 岁女性因进行性下肢无力持续 2 个月就诊。在此期间，她还经历了左侧下肢麻木和感觉障碍、2 次癫痫发作和便秘。临床和影像学评估提示诊断为合并左侧咽后肿块病变的脑脊髓炎。患者接受了病变的手术切除，随后症状得到缓解。术后病理与副神经节瘤一致。在最近的随访中，未发现肿瘤有局部复发或远处转移的证据。
据我们所知，我们的患者是第三例报道的咽旁副神经节瘤病例，也是唯一一例伴有副瘤性综合征的病例。
