Hippocampus. 2012 Oct;22(10):2012-31. doi: 10.1002/hipo.22067.
Work is reviewed that relates recognition memory to studies of synaptic plasticity mechanisms in perirhinal and prefrontal cortices. The aim is to consider evidence that perirhinal cortex and medial prefrontal cortex store rather than merely transmit information necessary for recognition memory and, if so, to consider what mechanisms are potentially available within these cortices for producing such storage through synaptic change. Interventions with known actions on plasticity mechanisms are reviewed in relation to their effects on recognition memory processes. These interventions importantly include those involving antagonism of glutamatergic and cholinergic receptors but also inhibition of plasticity consolidation and expression mechanisms. It is concluded that there is strong evidence that perirhinal cortex is involved in information storage necessary for object recognition memory and, moreover, that such storage involves synaptic weakening mechanisms including the removal of AMPA glutamate receptors from synapses. There is good evidence that medial prefrontal cortex is necessary for associative and temporal order recognition memory and that this cortex expresses plasticity mechanisms that potentially allow the storage of information. However, the case for medial prefrontal cortex acting as a store requires further support.
工作回顾了识别记忆与眶额和前额皮质中的突触可塑性机制研究之间的关系。目的是考虑这样一种证据，即边缘系统和内侧前额皮质存储而不仅仅是传递识别记忆所需的信息，如果是这样，那么考虑这些皮质中通过突触变化产生这种存储的潜在机制。回顾了已知对可塑性机制有作用的干预措施及其对识别记忆过程的影响。这些干预措施重要的包括涉及对抗谷氨酸能和胆碱能受体的干预措施，但也包括抑制可塑性巩固和表达机制的干预措施。结论是，有强有力的证据表明，边缘系统参与了对象识别记忆所需的信息存储，而且，这种存储涉及包括从突触上移除 AMPA 谷氨酸受体在内的突触弱化机制。有很好的证据表明，内侧前额皮质对于联想和时间顺序识别记忆是必要的，而且，这种皮质表达了潜在允许信息存储的可塑性机制。然而，内侧前额皮质作为一个存储库的作用还需要进一步的支持。
