Department of Oncology, Palacký University Medical School and Teaching Hospital, Fakultní nemocnice, Olomouc, Czech Republic.
Clin Chem Lab Med. 2013 Jan;51(1):99-112. doi: 10.1515/cclm-2012-0496.
Cancer represents a leading cause of death in the developed countries. The past 50 years have witnessed major progress in both laboratory medicine and clinical oncology that has translated into improved prognosis of cancer patients. From the humble beginnings as unrelated specialties, major advances in the understanding of molecular bases of cancer progression led to increased interactions between laboratory medicine and clinical (mostly medical) oncology. Laboratory medicine is now an integral part of the management of cancer patients. The many aspects of the role of laboratory medicine in clinical oncology include the determination of biomarkers that are used in establishing the diagnosis, predicting response to therapy or prognosis, study of the host response to tumor growth, detection of treatment toxicity and determining the concentrations of anticancer drugs.
癌症是发达国家的主要死亡原因。在过去的 50 年里，实验室医学和临床肿瘤学都取得了重大进展，这使得癌症患者的预后得到了改善。从最初互不相关的专业开始，对癌症进展分子基础的理解取得了重大进展，从而增加了实验室医学和临床（主要是医学）肿瘤学之间的相互作用。实验室医学现在是癌症患者管理的一个组成部分。实验室医学在临床肿瘤学中的许多作用包括确定生物标志物，这些标志物用于确定诊断、预测对治疗的反应或预后、研究宿主对肿瘤生长的反应、检测治疗毒性以及确定抗癌药物的浓度。
