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原发性全膝关节置换术感染粘质沙雷氏菌。

Primary total knee arthroplasty infected with Serratia marcescens.

作者信息

Mahmoud Samer S S, Odak Saurabh, Qazzafi Zaman, McNicholas M J

机构信息

Department of Trauma and Orthopaedics, University Hospital Aintree, Liverpool, UK.

出版信息

BMJ Case Rep. 2012 Sep 17;2012:bcr2012006179. doi: 10.1136/bcr-2012-006179.

DOI:10.1136/bcr-2012-006179
PMID:22987901
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4542562/
Abstract

We report an unusual case of a Serratia marcescens infection of total knee arthroplasty 4 weeks after the procedure following aspiration carried out on the ward (contrary to local protocol). This was successfully treated with thorough wound debridement, irrigation, change of the polyethylene liner and systemic antibiotics using intravenous meropenem for 3 weeks followed by oral ciprofloxacin for another 3 weeks. Our patient made an uneventful recovery and there was no reported recurrence of infection at 8 months of follow-up. We are unsure as to whether the infection was introduced at the time of the joint aspiration or was a complication of the initial procedure despite all the standard aseptic measures taken at the time of surgery.

摘要

我们报告了一例不寻常的病例,患者在病房进行抽吸(与当地规程相悖)4周后,全膝关节置换术后发生粘质沙雷氏菌感染。通过彻底的伤口清创、冲洗、更换聚乙烯衬垫以及使用静脉注射美罗培南进行3周的全身抗生素治疗,随后再口服环丙沙星3周,成功治愈了该感染。我们的患者恢复顺利,在8个月的随访中未报告感染复发。尽管手术时采取了所有标准的无菌措施,但我们不确定感染是在关节抽吸时引入的,还是初始手术的并发症。

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本文引用的文献

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Serratia marcescens is able to survive and proliferate in autophagic-like vacuoles inside non-phagocytic cells.黏质沙雷氏菌能够在非吞噬细胞的自噬样小泡中存活和增殖。
PLoS One. 2011;6(8):e24054. doi: 10.1371/journal.pone.0024054. Epub 2011 Aug 25.
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Infection following total knee arthroplasty: prevention and management.全膝关节置换术后感染:预防与处理
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Pharmacokinetic and pharmacodynamic properties of meropenem.美罗培南的药代动力学和药效学特性。
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Serratia marcescens prosthesis infection successfully treated with meropenem after imipenem failure.亚胺培南治疗失败后,美罗培南成功治愈粘质沙雷氏菌假体感染。
J Infect. 2005 Aug;51(2):E45-7. doi: 10.1016/j.jinf.2004.08.013.
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Epidemiology of total knee replacement in the United States Medicare population.美国医疗保险人群全膝关节置换术的流行病学
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Wound infection in hip and knee arthroplasty.髋膝关节置换术中的伤口感染
J Bone Joint Surg Br. 2000 May;82(4):561-5. doi: 10.1302/0301-620x.82b4.10305.
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Serratia marcescens contaminated disinfectants.粘质沙雷氏菌污染了消毒剂。
Lancet. 1981 May 23;1(8230):1154-5. doi: 10.1016/s0140-6736(81)92317-5.
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Orthopaedic infections by Serratia marcescens: a report of seven cases.粘质沙雷氏菌引起的骨科感染:7例报告
Scand J Infect Dis. 1987;19(1):69-75. doi: 10.3109/00365548709032380.