Department of Psychiatry, Sri. Ramachandra University, Chennai, Tamil Nadu, India.
Indian J Psychiatry. 2012 Apr;54(2):194-5. doi: 10.4103/0019-5545.99543.
Serotonin-reuptake inhibitors have come forth to become the mainstay of treatment in obsessive compulsive disorder (OCD), predominantly as a result of evidence from clinical psychopharmacological response studies. Comorbid psychiatric disorders frequent OCD patients, most often depression. Although selective serotonin reuptake inhibitors are effective in the treatment of both OCD and depressive disorder, all antidepressants are associated with treatment-emergent affective switch. We present a 48-year-old patient with OCD, on antidepressants, initially for OCD and later for depression as well. She switched to mania after 20 years of treatment, which responded to olanzapine and divalproex sodium.
选择性 5-羟色胺再摄取抑制剂已成为强迫症（OCD）治疗的主要方法，这主要是由于临床精神药理学反应研究的证据。共病精神障碍常伴有 OCD 患者，最常见的是抑郁症。虽然选择性 5-羟色胺再摄取抑制剂对 OCD 和抑郁障碍的治疗都有效，但所有抗抑郁药都与治疗后出现的情感转换有关。我们介绍了一位 48 岁的 OCD 患者，她最初因 OCD 而服用抗抑郁药，后来又因抑郁症而服用。她在治疗 20 年后转为躁狂，奥氮平和丙戊酸钠对此有效。
