Goswami Rudra Prosad, Mondal Swati, Basu Subrata, Karmakar Partha Sarathi, Ghosh Alakendu
Department of Medicine, Institute of Post Graduate Medical Education and Research, Kolkata, India.
Indian J Crit Care Med. 2012 Apr;16(2):106-8. doi: 10.4103/0972-5229.99128.
Benzodiazepine is a commonly encountered agent of poisoning, which is readily diagnosed by a pertinent history of drug ingestion and the clinical scenario. In the absence of a proper drug history, the diagnosis becomes challenging. Proper clinical assessment, urine assays and imaging play a very important role in reaching the diagnosis. We present a case of acute benzodiazepine poisoning without a history of drug intake. The key pointers toward diagnosis were an unarousable state with obstructive apnea. Magnetic resonance imaging (MRI) of the brain revealed peculiar symmetrical isolated globus pallidus T2 hyperintensity. We believe this to be the first report of isolated bilateral basal ganglia T2-weighted hyperintensity in MRI in the setting of acute benzodiazepine poisoning from India.
苯二氮䓬类药物是一种常见的中毒药物，通过相关的药物摄入史和临床情况很容易诊断。在缺乏确切用药史的情况下，诊断会变得具有挑战性。正确的临床评估、尿液检测和影像学检查在做出诊断方面起着非常重要的作用。我们报告一例无药物摄入史的急性苯二氮䓬类药物中毒病例。诊断的关键线索是处于无法唤醒状态并伴有阻塞性呼吸暂停。脑部磁共振成像（MRI）显示双侧苍白球出现特殊的对称性孤立性T2高信号。我们认为这是印度首例关于急性苯二氮䓬类药物中毒情况下MRI显示双侧基底节区孤立性T2加权高信号的报告。
