Metzer W S, Newton J E, Steele R W, Claybrook M, Paige S R, McMillan D E, Hays S
Department of Neurology, University of Arkansas for Medical Sciences, Little Rock.
J Neuroimmunol. 1990 Feb;26(2):179-81. doi: 10.1016/0165-5728(90)90089-6.
Fifty-three male, Caucasian, neuroleptic-treated patients with chronic schizophrenia were examined for the presence of tardive dyskinesia (TD) and were tissue typed. The group with TD (n = 25) was compared to the group without TD (n = 28). HLA-DR4 was more prevalent in the group with TD than in the group without TD, with a relative risk of 3.04 for TD with HLA-DR4 present, although this finding is not statistically significant when corrected for the number of nonparametric comparisons. Other investigations reported an association between HLA-B44 and TD, or between HLA-B44 and neuroleptic-induced parkinsonism. Potential explanations relating the findings of these investigations are discussed.
对53名接受抗精神病药物治疗的慢性精神分裂症男性白种患者进行迟发性运动障碍（TD）检查并进行组织分型。将患有TD的组（n = 25）与未患TD的组（n = 28）进行比较。HLA - DR4在患有TD的组中比在未患TD的组中更普遍，存在HLA - DR4时患TD的相对风险为3.04，尽管在校正非参数比较的数量后，这一发现无统计学意义。其他研究报告了HLA - B44与TD之间，或HLA - B44与抗精神病药物诱发的帕金森症之间的关联。讨论了与这些研究结果相关的潜在解释。
