Department of Radiology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Cancer Sci. 2012 Nov;103(11):1967-73. doi: 10.1111/j.1349-7006.2012.02392.x. Epub 2012 Sep 18.
Regression curves and local control rates of brain metastases after gamma knife treatment were evaluated to investigate differences in tumor response to radiation. A total of 203 metastases were serially evaluated using contrast-enhanced MRI (or computed tomography) at 1, 2, 3, 4.5 and 6 months after a 20-Gy dose. Differences were evaluated in regression curves and control rates between tumors ≥10 mm and tumors <10 mm in mean diameter, among three major histological subtypes of lung cancer, among adenocarcinomas of the lung, breast and colorectum, and between tumors in patients with above and below median hemoglobin levels. Smaller tumors shrank faster and yielded better control rates than larger tumors. Metastases from small cell and squamous cell carcinomas of the lung shrank faster than those from lung adenocarcinoma, but 6-month control rates were not different. Breast adenocarcinomas tended to shrink faster than lung adenocarcinomas, but the control rates were not different among adenocarcinomas of the lung, breast and colorectum. Tumors in patients with higher hemoglobin levels tended to shrink faster but the control rates were not different. Small cell and squamous cell carcinomas of the lung regress more rapidly than adenocarcinomas, although local control rates might not differ significantly.
评估了伽玛刀治疗后脑转移瘤的回归曲线和局部控制率，以研究肿瘤对辐射的反应差异。在 20 Gy 剂量后 1、2、3、4.5 和 6 个月，使用对比增强 MRI（或计算机断层扫描）对 203 个转移瘤进行连续评估。评估了肿瘤直径≥10 mm 和肿瘤直径<10 mm 的肿瘤、三种主要肺癌组织学亚型、肺癌、乳腺和结直肠癌腺癌、以及血红蛋白中位数以上和以下患者的肿瘤之间的回归曲线和控制率差异。较小的肿瘤收缩更快，控制率更好。小细胞和肺鳞癌转移瘤的收缩速度快于肺腺癌，但 6 个月的控制率无差异。乳腺腺癌的收缩速度快于肺腺癌，但肺、乳腺和结直肠腺癌的控制率无差异。血红蛋白水平较高的患者的肿瘤收缩速度较快，但控制率无差异。小细胞和肺鳞癌比腺癌消退更快，尽管局部控制率可能没有显著差异。
