Xu Li-Ping, Ren Rong-Na, Zhu Shao-Bo, Zhuang Hong-Mei, Huang Zhong-Ling, Yang Hong
Department of Pediatrics, Fujian Medical University, Zhangzhou, Fujian, China.
Zhongguo Dang Dai Er Ke Za Zhi. 2012 Sep;14(9):661-3.
To explore the association between chorioamnionitis and brain injury in preterm infants.
A total of 88 preterm infants (28-34 weeks), who were born between June 2008 and June 2011, were divided into a case group (n=41) and a control group (n=47) according to whether or not they had chorioamnionitis. All the infants were examined by brain ultrasonography periodically after birth and underwent brain diffusion weighted imaging (DWI) between 3 and 7 days after birth. The two groups were compared in terms of the incidence of periventricular leukomalacia (PVL) and periventricular and intraventricular hemorrhage (PVH-IVH) by brain magnetic resonance imaging (MRI) at the corrected gestational age of 40 weeks.
There was statistical significance in the incidence of PVL between the case and the control groups (32% vs 6%; P<0.05), but no significant difference in the incidence of PVH-IVH between the two groups (27% vs 23%; P>0.05).
Chorioamnionitis is associated with brain injury in preterm infants, increasing the incidence of PVL but having little influence over the incidence of PVH-IVH.
探讨绒毛膜羊膜炎与早产儿脑损伤之间的关联。
选取2008年6月至2011年6月间出生的88例孕周28 - 34周的早产儿，根据是否患有绒毛膜羊膜炎分为病例组（n = 41）和对照组（n = 47）。所有婴儿出生后定期接受脑超声检查，并在出生后3至7天进行脑弥散加权成像（DWI）。在矫正胎龄40周时，通过脑磁共振成像（MRI）比较两组脑室周围白质软化（PVL）和脑室周围及脑室内出血（PVH-IVH）的发生率。
病例组与对照组PVL发生率有统计学意义（32%对6%；P < 0.05），但两组PVH-IVH发生率无显著差异（27%对23%；P > 0.05）。
绒毛膜羊膜炎与早产儿脑损伤有关，增加了PVL的发生率，但对PVH-IVH的发生率影响不大。
