Thomas-Antérion C, Richard-Mornas A
Unité de neuropsychologie-CM2R, CHU Nord, 25, boulevard Pasteur, 42100 Saint-Étienne, France.
Rev Neurol (Paris). 2013 Feb;169(2):97-107. doi: 10.1016/j.neurol.2012.05.011. Epub 2012 Sep 16.
Psychiatric diagnoses are frequent in memory units, but most neurologists do not feel comfortable about making the diagnosis of psychopathologic cognitive complaint or disorder. The full diagnosis usually requires careful history taking and a neuropsychological examination followed by a clear joint explanation to the patient. There are no good validated clinical signs to distinguish organic memory complaints from psychological disorders, but a nonorganic pattern, as seen in somatic conversion disorder, can be suggestive of a "cognitivoform" disorder. Cognitive doubt is a frequent symptom of anxiety. Bradypsychia is a frequent symptom of depression. We report 50 patients attending their first neurological memory consultation in university hospital for whom a de novo diagnosis of psychopathologic disorder was established on the basis of the clinical setting, observation, examination and neuropsychological tests. These psychopathologic disorders accounted for 40.3% of first-consultation diagnoses. In 76% of cases, the neuropsychological examination was normal. Nine subjects had mild cognitive impairment, concerning executive functions in six and several domains in three. Simulation with atypical neuropsychological pattern was distinguished in three patients. The diagnoses were:psychosis (n=9), traumatic stress (n=5), depression (n=7), anxiety or obsession/compulsion (n=13), hypochondria and "cognitivoform" disorders (n=13). In this study, few patients consulted with a known psychiatric diagnosis. Psychiatric co-morbidity was common. In the memory unit, listening carefully to ascertain the psychic, somatic and social situation of each individual patient appears to be as important as evaluating cognition. The neurologist can rule out organic disorders or an exaggeration of somatic symptoms and determine the precise etiology in order to build a rationale for treatment. The neurologist can also avert an overconsumption of complementary explorations. In conclusion, this study shows first that psychopathologic disorders are commonly encountered in a neurological memory unit, emphasizing the need for training for the neurologist and collaboration with a psychiatrist, and secondly that the role of the memory unit cannot be limited to the diagnosis of Alzheimer's disease.
精神科诊断在记忆门诊很常见,但大多数神经科医生对做出精神病理认知主诉或障碍的诊断并不自信。完整的诊断通常需要仔细采集病史、进行神经心理学检查,然后向患者进行清晰的联合解释。目前尚无有效的临床体征来区分器质性记忆主诉与心理障碍,但躯体转换障碍中所见的非器质性模式可能提示“认知形式”障碍。认知怀疑是焦虑的常见症状。思维迟缓是抑郁的常见症状。我们报告了50例在大学医院首次进行神经记忆门诊咨询的患者,根据临床情况、观察、检查和神经心理学测试,对他们重新诊断为精神病理障碍。这些精神病理障碍占首次咨询诊断的40.3%。76%的病例神经心理学检查正常。9名受试者有轻度认知障碍,其中6名涉及执行功能,3名涉及多个领域。3例患者表现出非典型神经心理学模式的伪装。诊断结果为:精神病(n = 9)、创伤后应激障碍(n = 5)、抑郁症(n = 7)、焦虑症或强迫症(n = 13)、疑病症和“认知形式”障碍(n = 13)。在本研究中,很少有患者以已知的精神科诊断前来咨询。精神科共病很常见。在记忆门诊,仔细倾听以确定每个患者的心理、躯体和社会状况似乎与评估认知同样重要。神经科医生可以排除器质性疾病或躯体症状的夸大,并确定确切病因,以便制定治疗依据。神经科医生还可以避免过度进行辅助检查。总之,本研究首先表明精神病理障碍在神经记忆门诊很常见,强调了神经科医生培训以及与精神科医生合作的必要性,其次表明记忆门诊的作用不能局限于阿尔茨海默病的诊断。