Department of Counseling, Educational Psychology and Special Education, Michigan State University, Erickson Hall, 620 Farm Lane Room 455, East Lansing, MI 48824, United States.
Epilepsy Res. 2013 Feb;103(2-3):231-6. doi: 10.1016/j.eplepsyres.2012.08.011. Epub 2012 Sep 16.
Cognitive and psychomotor slowing is a complication of epilepsy and is less often a focus of investigation relative to other cognitive domains (e.g., memory). A diversity of tasks has been used to examine psychomotor slowing in epilepsy, but it remains unknown whether the degree of epilepsy-related slowing is fixed or is exacerbated with increasing task demand. Also unknown is to what degree age related slowing is accelerated in epilepsy. Participants with temporal lobe epilepsy (n=50) were compared to healthy controls (n=69) across three tasks of psychomotor speed with varied complexity. Performance was examined as a function of group (epilepsy, controls), task complexity (simple, intermediate, complex), and chronological age. The results showed that speed of performance declined across the epilepsy and control participants as a function of task complexity. Epilepsy participants were significantly slower than controls across the three tasks, and there was a significant three-way interaction (group by task complexity by age). These results demonstrate that psychomotor slowing is related to task complexity in both epilepsy and healthy control participants, always greater in epilepsy participants, and there is a significant age acceleration of psychomotor slowing in the epilepsy group that is magnified by complex tasks.
认知和运动迟缓是癫痫的一种并发症，相对于其他认知领域（例如记忆），它较少成为研究的焦点。已经使用了多种任务来检查癫痫中的运动迟缓，但尚不清楚与癫痫相关的运动迟缓程度是固定的，还是随着任务需求的增加而加剧。也不知道在癫痫中，与年龄相关的运动迟缓加速到什么程度。将颞叶癫痫患者（n=50）与健康对照组（n=69）在三个具有不同复杂性的运动速度任务中进行比较。将表现作为组（癫痫、对照组）、任务复杂性（简单、中等、复杂）和年龄的函数进行检查。结果表明，随着任务复杂性的增加，癫痫和对照组参与者的表现速度都有所下降。癫痫患者在三个任务中的表现均明显慢于对照组，并且存在显著的三向交互作用（组间、任务复杂性和年龄）。这些结果表明，在癫痫和健康对照组参与者中，运动迟缓与任务复杂性相关，在癫痫患者中总是更严重，并且在癫痫组中存在显著的运动迟缓的年龄加速，而复杂任务会加剧这种加速。
