颞叶癫痫患者白质完整性改变：与认知和临床特征的相关性。
Altered white matter integrity in temporal lobe epilepsy: association with cognitive and clinical profiles.
机构信息
Department of Neurology, University of California, Irvine, CA 92868, USA.
出版信息
Epilepsia. 2010 Apr;51(4):536-45. doi: 10.1111/j.1528-1167.2009.02508.x. Epub 2010 Feb 3.
PURPOSE
Diffusion tensor imaging (DTI) studies have reported substantial white matter abnormalities in patients with temporal lobe epilepsy (TLE). However, limited data exist regarding the extent of white matter tract abnormalities, cognitive effects of these abnormalities, and relationship to clinical factors. The current study examined these issues in subjects with chronic TLE.
METHODS
DTI data were obtained in 12 TLE subjects and 10 age-matched healthy controls. Voxel-wise statistical analysis of fractional anisotropy (FA) was carried out using tract-based spatial statistics (TBSS). White matter integrity was correlated with cognitive performance and epilepsy-related clinical parameters.
RESULTS
Subjects with TLE, as compared to healthy controls, demonstrated four clusters of reduced FA, in anterior temporal lobe, mesial temporal lobe, and cerebellum ipsilateral, as well as frontoparietal lobe contralateral to the side of seizure onset. Mean FA was positively correlated with delayed memory, in anterior temporal lobe; and immediate memory, in mesial temporal lobe. Lower FA values in the posterior region of corpus callosum were related to earlier age of seizure onset.
CONCLUSION
TLE is associated with widespread disturbances in white matter tracts and these changes have important cognitive and clinical consequences.
目的
弥散张量成像（DTI）研究报告称，颞叶癫痫（TLE）患者存在大量的白质异常。然而，关于白质束异常的范围、这些异常的认知影响以及与临床因素的关系，数据有限。本研究在慢性 TLE 患者中检查了这些问题。
方法
对 12 例 TLE 患者和 10 名年龄匹配的健康对照者进行 DTI 数据采集。采用基于束的空间统计学（TBSS）对各向异性分数（FA）进行体素-wise 统计分析。白质完整性与认知表现和与癫痫相关的临床参数相关。
结果
与健康对照组相比，TLE 患者在前颞叶、内侧颞叶和对侧额顶叶，以及与癫痫发作侧同侧的小脑，有四个 FA 降低的簇。在前颞叶，平均 FA 与延迟记忆呈正相关；在海马，与即刻记忆呈正相关。胼胝体后部 FA 值较低与癫痫发作年龄较早有关。
结论
TLE 与广泛的白质束紊乱有关，这些变化对白质束具有重要的认知和临床意义。
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