Mirea Oana, Donoiu I, Pleşea I E
Department of Cardiology, University of Medicine and Pharmacy of Craiova, Romania.
Rom J Morphol Embryol. 2012;53(3):473-7.
Aging is associated with changes in arterial wall structure and function that exceed physiological adaptation, with an increased risk of cardiovascular events. The most consistent structural changes are luminal enlargement (dilatation), wall thickening (remodeling), and a reduction of elastic properties. Endothelial dysfunction plays an important role in the functional changes that occur with age. New target therapies to prevent or reverse this process are under evaluation.
衰老与动脉壁结构和功能的变化相关，这些变化超出了生理适应范围，心血管事件风险增加。最一致的结构变化是管腔扩大（扩张）、管壁增厚（重塑）以及弹性特性降低。内皮功能障碍在随年龄发生的功能变化中起重要作用。预防或逆转这一过程的新靶向疗法正在评估中。
